Detailed information of TA system TA243087

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprG3-SprA2AS/-
• Location: 2202606..2202804
• Replicon: chromosome
• Accession: NZ_CP096526
• Organism: Staphylococcus aureus strain RIVM_M087195

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: M1F51_RS10815
• Protein ID: WP_001802298.1
• Coordinates: 2202700..2202804 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2202606..2202644 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1F51_RS10790 (M1F51_10765)	2198726..2199391	-	666	WP_001024099.1	SDR family oxidoreductase	-
M1F51_RS10795 (M1F51_10770)	2199543..2199863	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
M1F51_RS10800 (M1F51_10775)	2199865..2200845	+	981	WP_000019735.1	CDF family zinc efflux transporter CzrB	-
M1F51_RS10805 (M1F51_10780)	2201111..2202202	+	1092	WP_000495673.1	hypothetical protein	-
M1F51_RS10810 (M1F51_10785)	2202586..2202660	+	75	Protein_2089	hypothetical protein	-
-	2202606..2202644	+	39	-	-	Antitoxin
M1F51_RS10815 (M1F51_10790)	2202700..2202804	-	105	WP_001802298.1	hypothetical protein	Toxin
M1F51_RS10820 (M1F51_10795)	2203484..2203642	+	159	WP_001792784.1	hypothetical protein	-
M1F51_RS10825 (M1F51_10800)	2203751..2204518	-	768	WP_001095317.1	IS21-like element helper ATPase IstB	-
M1F51_RS10830 (M1F51_10805)	2204530..2205765	-	1236	WP_001215401.1	IS21 family transposase	-
M1F51_RS10835 (M1F51_10810)	2206281..2206373	+	93	WP_000220902.1	hypothetical protein	-
M1F51_RS10840 (M1F51_10815)	2206503..2207360	-	858	WP_000370942.1	HAD family hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T243087 WP_001802298.1 NZ_CP096526:c2202804-2202700 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T243087 NZ_OW969711:c3955519-3955166 [Citrobacter koseri]
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGCGACGCTATGTCTGTCGCCCGTGGCAGTCTGGCAAATGCTGCTTGC
ACGCCTGCTAGAACAACATTATGGCCTAACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTTCGGGCTGGTTCGTATTGATCGCAGGGGATTC
AACTGGCAAGAACAGTCCCCATATCTGCGGGCAGTCGATATTCTGAGGGCGCGACAGGCAACTGGTTTATTGAAAAGAAA
TCGTATTAGCGCGGCACGGGAACATTGGGAATAG

Antitoxin

Nucleotide

• Length: 39 bp

>AT243087 NZ_CP096526:2202606-2202644 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin