Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | TMCS/- |
| Location | 369022..369601 | Replicon | chromosome |
| Accession | NZ_CP096522 | ||
| Organism | Staphylococcus aureus strain RIVM_M085090 | ||
Toxin (Protein)
| Gene name | MW1434 | Uniprot ID | A0A4P7P609 |
| Locus tag | M1F52_RS01680 | Protein ID | WP_001025401.1 |
| Coordinates | 369022..369267 (+) | Length | 82 a.a. |
Antitoxin (RNA)
| Gene name | MW1433 | ||
| Locus tag | - | ||
| Coordinates | 369236..369601 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M1F52_RS01620 (M1F52_01610) | 364548..364694 | - | 147 | WP_074370993.1 | hypothetical protein | - |
| M1F52_RS01625 (M1F52_01615) | 364924..365508 | - | 585 | WP_031918390.1 | hypothetical protein | - |
| M1F52_RS01630 (M1F52_01620) | 365526..365987 | - | 462 | WP_000525004.1 | hypothetical protein | - |
| M1F52_RS01635 (M1F52_01625) | 366000..366314 | - | 315 | WP_000333630.1 | helix-turn-helix transcriptional regulator | - |
| M1F52_RS01640 (M1F52_01630) | 366466..366702 | + | 237 | WP_001121027.1 | helix-turn-helix transcriptional regulator | - |
| M1F52_RS01645 (M1F52_01635) | 366716..367492 | + | 777 | WP_001148544.1 | Rha family transcriptional regulator | - |
| M1F52_RS01650 (M1F52_01640) | 367521..367664 | + | 144 | WP_000939498.1 | hypothetical protein | - |
| M1F52_RS01655 (M1F52_01645) | 367654..367863 | - | 210 | WP_000642492.1 | hypothetical protein | - |
| M1F52_RS01660 (M1F52_01650) | 367919..368068 | + | 150 | WP_000771849.1 | hypothetical protein | - |
| M1F52_RS01665 (M1F52_01655) | 368109..368321 | - | 213 | WP_000362644.1 | hypothetical protein | - |
| M1F52_RS01670 (M1F52_01660) | 368391..368588 | + | 198 | WP_001148860.1 | hypothetical protein | - |
| M1F52_RS01675 (M1F52_01665) | 368575..368955 | - | 381 | WP_000773059.1 | DUF2513 domain-containing protein | - |
| M1F52_RS01680 (M1F52_01670) | 369022..369267 | + | 246 | WP_001025401.1 | DUF2829 domain-containing protein | Toxin |
| M1F52_RS01685 (M1F52_01675) | 369236..369601 | - | 366 | WP_001128432.1 | hypothetical protein | Antitoxin |
| M1F52_RS01690 (M1F52_01680) | 369656..369871 | + | 216 | WP_001097552.1 | hypothetical protein | - |
| M1F52_RS01695 (M1F52_01685) | 369896..370159 | + | 264 | WP_001124160.1 | helix-turn-helix domain-containing protein | - |
| M1F52_RS01700 (M1F52_01690) | 370172..370333 | + | 162 | WP_001285954.1 | DUF1270 domain-containing protein | - |
| M1F52_RS01705 (M1F52_01695) | 370416..370739 | + | 324 | WP_031903993.1 | hypothetical protein | - |
| M1F52_RS01710 (M1F52_01700) | 370754..371116 | + | 363 | WP_031901863.1 | hypothetical protein | - |
| M1F52_RS01715 (M1F52_01705) | 371113..372279 | + | 1167 | WP_267408451.1 | DUF2800 domain-containing protein | - |
| M1F52_RS01720 (M1F52_01710) | 372306..372860 | + | 555 | WP_000647288.1 | DUF2815 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | geh | 358050..407190 | 49140 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 82 a.a. Molecular weight: 9468.72 Da Isoelectric Point: 5.7783
>T243071 WP_001025401.1 NZ_CP096522:369022-369267 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F
Download Length: 246 bp
>T243071 NZ_OW969659:c5338293-5337808 [Klebsiella oxytoca]
ATGATCTCCGCCCCAGAGCCGCTTCAGGCCGGGCATATTCTTACCCCGTTCTATTGTGGCGTGGATTCTATGGATAACTG
GCTGAAACAGCGAGCGATGAAGAACCAGCTTTCTGGGGCGTCCCGCACGTTTGTTTGCTGCGACGATGCTAAGGTGATGG
CGTACTACTCGCTGGCTTCCAGCGCTGTGGCGACAAATACTGCGCCCGGACGCTTTCGCCGCAATATGCCTGACCCTATC
CCGGTTGTGGTGCTGGGACGTCTGGCGGTGGATCGAACTCTACATGGGCAGGGCGTTGGGCGGGCGCTGGTGAGGGATGC
CGGGCTACGGGTGATTCAGGTGGCAGAAACTATCGGCATTCGCGGGATGTTGGTTCACGCCCTGTCGGATGAAGCGCGGG
AGTTTTACCTGCGTGTTGGGTTTGAGCCGTCGCCGATAGACCCGATGATGTTGATGGTGACGTTGGGGGATTTAGTTCAT
GCTTGA
ATGATCTCCGCCCCAGAGCCGCTTCAGGCCGGGCATATTCTTACCCCGTTCTATTGTGGCGTGGATTCTATGGATAACTG
GCTGAAACAGCGAGCGATGAAGAACCAGCTTTCTGGGGCGTCCCGCACGTTTGTTTGCTGCGACGATGCTAAGGTGATGG
CGTACTACTCGCTGGCTTCCAGCGCTGTGGCGACAAATACTGCGCCCGGACGCTTTCGCCGCAATATGCCTGACCCTATC
CCGGTTGTGGTGCTGGGACGTCTGGCGGTGGATCGAACTCTACATGGGCAGGGCGTTGGGCGGGCGCTGGTGAGGGATGC
CGGGCTACGGGTGATTCAGGTGGCAGAAACTATCGGCATTCGCGGGATGTTGGTTCACGCCCTGTCGGATGAAGCGCGGG
AGTTTTACCTGCGTGTTGGGTTTGAGCCGTCGCCGATAGACCCGATGATGTTGATGGTGACGTTGGGGGATTTAGTTCAT
GCTTGA
Antitoxin
Download Length: 366 bp
>AT243071 NZ_CP096522:c369601-369236 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAAAACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAAAACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
