Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2371333..2371517 Replicon chromosome
Accession NZ_CP096274
Organism Staphylococcus aureus strain FJ0322

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag M1E50_RS11625 Protein ID WP_000482652.1
Coordinates 2371333..2371440 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2371457..2371517 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1E50_RS11600 2366695..2367168 + 474 WP_000456489.1 GyrI-like domain-containing protein -
M1E50_RS11605 2367291..2368502 - 1212 WP_001191922.1 multidrug effflux MFS transporter -
M1E50_RS11610 2368684..2369343 - 660 WP_000831298.1 membrane protein -
M1E50_RS11615 2369403..2370545 - 1143 WP_001176863.1 glycerate kinase -
M1E50_RS11620 2370813..2371199 + 387 WP_000779357.1 flippase GtxA -
M1E50_RS11625 2371333..2371440 + 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
- 2371457..2371517 - 61 - - Antitoxin
M1E50_RS11630 2372143..2373906 + 1764 WP_001064837.1 ABC transporter ATP-binding protein -
M1E50_RS11635 2373931..2375664 + 1734 WP_049307645.1 ABC transporter ATP-binding protein -
M1E50_RS11640 2375895..2376062 + 168 WP_001789205.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T243057 WP_000482652.1 NZ_CP096274:2371333-2371440 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T243057 NZ_OW968431:3862841-3863059 [Klebsiella quasipneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGCCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAACAAATATGAACTTTCTGATAATGAGCTGGCGGTATTTTACTCAGCCGCCGATCATCGTCTGGCTGAAC
TGACTATGAATAAGCTGTACGATAAAATCCCGACGTCCGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 61 bp

>AT243057 NZ_CP096274:c2371517-2371457 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References