Detailed information of TA system TA243045

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2656321..2656600
• Replicon: chromosome
• Accession: NZ_CP096272
• Organism: Staphylococcus aureus strain FJ0318

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: M1E49_RS13105
• Protein ID: WP_001802298.1
• Coordinates: 2656321..2656425 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2656421..2656600 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1E49_RS13080	2651705..2652487	+	783	WP_000908177.1	ABC transporter ATP-binding protein	-
M1E49_RS13085	2652555..2653412	+	858	WP_000370924.1	HAD family hydrolase	-
M1E49_RS13090	2654117..2654209	-	93	WP_001790138.1	hypothetical protein	-
M1E49_RS13095	2654498..2655634	+	1137	WP_000115564.1	SAP domain-containing protein	-
M1E49_RS13100	2655677..2656160	+	484	Protein_2542	recombinase family protein	-
M1E49_RS13105	2656321..2656425	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2656421..2656600	-	180	-	-	Antitoxin
M1E49_RS13115	2656868..2657959	-	1092	WP_000495683.1	hypothetical protein	-
M1E49_RS13120	2658225..2659205	-	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
M1E49_RS13125	2659207..2659527	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
M1E49_RS13130	2659679..2660344	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T243045 WP_001802298.1 NZ_CP096272:2656321-2656425 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T243045 NZ_OW968417:c3744372-3743962 [Enterobacter cloacae]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCATGGGCTGGTCGCGGC
AATGGTGTTATTGGTGCCGTGGCCGCTAAGCTATACCCCTCTGTGGCTGCTTTTGCTGTCGTTTGTAGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATGATAGGGACGCCGTGGATGCTCAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGACAATCGTCG
CCAGCACCTGTGGCTGGCAGCAGACAGTATGGATCCTGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin

Nucleotide

• Length: 180 bp

>AT243045 NZ_CP096272:c2656600-2656421 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTC
AAAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin