Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2339435..2339958 Replicon chromosome
Accession NZ_CP096272
Organism Staphylococcus aureus strain FJ0318

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0E1VXK4
Locus tag M1E49_RS11485 Protein ID WP_000074045.1
Coordinates 2339692..2339958 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0E1VMY7
Locus tag M1E49_RS11480 Protein ID WP_000587619.1
Coordinates 2339435..2339692 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1E49_RS11460 (2334513) 2334513..2335706 + 1194 WP_000675407.1 MFS transporter -
M1E49_RS11465 (2335930) 2335930..2336679 - 750 WP_000072465.1 CPBP family lipoprotein N-acylation protein LnsB -
M1E49_RS11470 (2336875) 2336875..2338452 + 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
M1E49_RS11475 (2338620) 2338620..2339075 - 456 WP_000732079.1 DUF1307 domain-containing protein -
M1E49_RS11480 (2339435) 2339435..2339692 + 258 WP_000587619.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M1E49_RS11485 (2339692) 2339692..2339958 + 267 WP_000074045.1 Txe/YoeB family addiction module toxin Toxin
M1E49_RS11490 (2340313) 2340313..2341389 + 1077 WP_001076671.1 M42 family metallopeptidase -
M1E49_RS11495 (2341637) 2341637..2342299 + 663 WP_000923525.1 ATP-binding cassette domain-containing protein -
M1E49_RS11500 (2342292) 2342292..2343068 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
M1E49_RS11505 (2343464) 2343464..2344651 + 1188 WP_000026194.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10632.36 Da        Isoelectric Point: 10.2519

>T243040 WP_000074045.1 NZ_CP096272:2339692-2339958 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

>T243040 NZ_OW968349:c1963-1625 [Klebsiella oxytoca]
GTGACACAATATTGTCCGGCTAGAGGTGATGTGATTTTGTTGGATTTCAATCCTCAATCGGGTCATGAGCAGGCAGGTAA
AAGGCCTGCTCTTGTCATTTCTGATGACATGTTTAATCAGGTGACTGGCTTTGCAGTCGTTTGCCCAATCACTAATCAGT
CAAAAAATTATCCATTCGAGGTGCCTGTAGTTGGTGCTAAAAAAACTACAGGTGTCATTTTGGCAGATCAGTTCAAGTCT
TTGGACTGGAAATCAAGACAAGCGCATACCATTGATGCTGTCTCGGCTGCTACTGTTGAGAGCGTAGTTTCTCTTGTTTC
AAAGATAATCAAAGCTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9735.76 Da        Isoelectric Point: 4.1958

>AT243040 WP_000587619.1 NZ_CP096272:2339435-2339692 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT243040 NZ_OW968349:c2190-1960 [Klebsiella oxytoca]
ATGACTACGGCTATCGGTAAGTGGGGTAATGGTGCGGGTTTGCGCATTCCTCAGCCGTTCATGAAGCAGCTTGGGCTTAG
TATTGGTGATGAGGTTAAATTCCACGTCACGGAGAAAAAATTAGTAATAACTAAGTCTGGCCCAACGCTCGAGGAACTGC
TGGGACAGTGCAATCCGGAAAATCGCCATCAGGAATATTTTTGCGAGTCTCAGGGTAAGGAGATGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1VXK4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1VMY7

References