Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/- |
| Location | 958535..958949 | Replicon | chromosome |
| Accession | NZ_CP096272 | ||
| Organism | Staphylococcus aureus strain FJ0318 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | M1E49_RS04790 | Protein ID | WP_001065064.1 |
| Coordinates | 958698..958949 (-) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | M1E49_RS04785 | Protein ID | WP_000028424.1 |
| Coordinates | 958535..958708 (-) | Length | 58 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M1E49_RS04745 (954904) | 954904..956181 | - | 1278 | WP_000169946.1 | PBSX family phage terminase large subunit | - |
| M1E49_RS04750 (956168) | 956168..956608 | - | 441 | WP_001003271.1 | terminase small subunit | - |
| M1E49_RS04755 (956795) | 956795..957214 | - | 420 | WP_271229962.1 | transcriptional regulator | - |
| M1E49_RS04760 (957229) | 957229..957375 | - | 147 | WP_000990005.1 | hypothetical protein | - |
| M1E49_RS04765 (957487) | 957487..957591 | - | 105 | Protein_910 | hypothetical protein | - |
| M1E49_RS04770 (957588) | 957588..957794 | - | 207 | WP_271229963.1 | DUF1381 domain-containing protein | - |
| M1E49_RS04775 (957831) | 957831..958358 | - | 528 | WP_001061837.1 | dUTPase | - |
| M1E49_RS04780 (958373) | 958373..958534 | - | 162 | WP_000889684.1 | hypothetical protein | - |
| M1E49_RS04785 (958535) | 958535..958708 | - | 174 | WP_000028424.1 | hypothetical protein | Antitoxin |
| M1E49_RS04790 (958698) | 958698..958949 | - | 252 | WP_001065064.1 | DUF1024 family protein | Toxin |
| M1E49_RS04795 (958963) | 958963..959205 | - | 243 | WP_000131366.1 | SAV1978 family virulence-associated passenger protein | - |
| M1E49_RS04800 (959209) | 959209..959577 | - | 369 | WP_000101274.1 | SA1788 family PVL leukocidin-associated protein | - |
| M1E49_RS04805 (959590) | 959590..959994 | - | 405 | WP_000401969.1 | RusA family crossover junction endodeoxyribonuclease | - |
| M1E49_RS04810 (960003) | 960003..960221 | - | 219 | WP_000338528.1 | hypothetical protein | - |
| M1E49_RS04815 (960228) | 960228..961112 | - | 885 | WP_271229964.1 | DnaD domain protein | - |
| M1E49_RS04820 (961142) | 961142..961612 | - | 471 | WP_029549393.1 | single-stranded DNA-binding protein | - |
| M1E49_RS04825 (961613) | 961613..962230 | - | 618 | WP_071621397.1 | MBL fold metallo-hydrolase | - |
| M1E49_RS04830 (962311) | 962311..963231 | - | 921 | WP_000138475.1 | recombinase RecT | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 929308..978093 | 48785 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9377.26 Da Isoelectric Point: 3.7128
>T243038 WP_001065064.1 NZ_CP096272:c958949-958698 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY
Download Length: 252 bp
>T243038 NZ_OW968347:c4633698-4633441 [Klebsiella oxytoca]
ATGAATCTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCTAAAGGTGGCCGGATCGCGCATATTCGCGATGCATC
AGGCCGCGTAACCTCTGTTGAATGCTATAGCCGCGAAGGGCTCCTGCTCAGCGACTGCACGCTCGCCGTTTTCAAAAAAC
TCAAAACCAAAAAACTCATTAAGTCCGTCAACGGGCAGCCCTACCGTATCAATACCACCGGGCTGAACAACGTTCGCGCT
CAGCTGGACAACCGCTAA
ATGAATCTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCTAAAGGTGGCCGGATCGCGCATATTCGCGATGCATC
AGGCCGCGTAACCTCTGTTGAATGCTATAGCCGCGAAGGGCTCCTGCTCAGCGACTGCACGCTCGCCGTTTTCAAAAAAC
TCAAAACCAAAAAACTCATTAAGTCCGTCAACGGGCAGCCCTACCGTATCAATACCACCGGGCTGAACAACGTTCGCGCT
CAGCTGGACAACCGCTAA
Antitoxin
Download Length: 58 a.a. Molecular weight: 6468.29 Da Isoelectric Point: 4.2484
>AT243038 WP_000028424.1 NZ_CP096272:c958708-958535 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
Download Length: 174 bp
>AT243038 NZ_OW968347:c4633430-4632879 [Klebsiella oxytoca]
ATGACAAACCATAACTTCACCTTTCACATCACCTCAGAGCGTGATGCTGATGATATTCGCGAAGTTGAAACCCGGGCCTT
CGGCTTTAGCAAAGAGGCCGATCTGGTTGCCGCTTTGCTCAACGATGAAAGTGCTCACCCGAGCTTATCTCTGCTGGCCA
AACATAATGGAAAAGCAGTTGGGCATATTTTGTTCACCCTGGCGACGTTCAAAGGGGAGTCTGACTCTCCGATGATGCAT
ATCCTTGCCCCTCTGGCGGTGGTGCCGGAATACCAGGGCATGGGTGTTGGCGGATTACTTATCCAAAGCGGTATTGAGCA
TCTGAAGGCAATGGGGAGCCTGGCGGTATTCGTTCTGGGACATGCCACTTATTACCCGCGGCATGGCTTTGAACCCTGTG
CCGGAGATAAAGGCTATCCGGCGCCTTATCCCATTCCCGAGGAGCATAAAGCCTGCTGGATGCTGCAGCGGCTTTCGTCC
CGGCCGCTGGGGATAACCGGTCAGATACAGTGCGCCCGGGCGTTAATGAAACCCGAGCACTGGCGCGAGTAA
ATGACAAACCATAACTTCACCTTTCACATCACCTCAGAGCGTGATGCTGATGATATTCGCGAAGTTGAAACCCGGGCCTT
CGGCTTTAGCAAAGAGGCCGATCTGGTTGCCGCTTTGCTCAACGATGAAAGTGCTCACCCGAGCTTATCTCTGCTGGCCA
AACATAATGGAAAAGCAGTTGGGCATATTTTGTTCACCCTGGCGACGTTCAAAGGGGAGTCTGACTCTCCGATGATGCAT
ATCCTTGCCCCTCTGGCGGTGGTGCCGGAATACCAGGGCATGGGTGTTGGCGGATTACTTATCCAAAGCGGTATTGAGCA
TCTGAAGGCAATGGGGAGCCTGGCGGTATTCGTTCTGGGACATGCCACTTATTACCCGCGGCATGGCTTTGAACCCTGTG
CCGGAGATAAAGGCTATCCGGCGCCTTATCCCATTCCCGAGGAGCATAAAGCCTGCTGGATGCTGCAGCGGCTTTCGTCC
CGGCCGCTGGGGATAACCGGTCAGATACAGTGCGCCCGGGCGTTAATGAAACCCGAGCACTGGCGCGAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|