Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 958535..958949 Replicon chromosome
Accession NZ_CP096272
Organism Staphylococcus aureus strain FJ0318

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag M1E49_RS04790 Protein ID WP_001065064.1
Coordinates 958698..958949 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M1E49_RS04785 Protein ID WP_000028424.1
Coordinates 958535..958708 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1E49_RS04745 (954904) 954904..956181 - 1278 WP_000169946.1 PBSX family phage terminase large subunit -
M1E49_RS04750 (956168) 956168..956608 - 441 WP_001003271.1 terminase small subunit -
M1E49_RS04755 (956795) 956795..957214 - 420 WP_271229962.1 transcriptional regulator -
M1E49_RS04760 (957229) 957229..957375 - 147 WP_000990005.1 hypothetical protein -
M1E49_RS04765 (957487) 957487..957591 - 105 Protein_910 hypothetical protein -
M1E49_RS04770 (957588) 957588..957794 - 207 WP_271229963.1 DUF1381 domain-containing protein -
M1E49_RS04775 (957831) 957831..958358 - 528 WP_001061837.1 dUTPase -
M1E49_RS04780 (958373) 958373..958534 - 162 WP_000889684.1 hypothetical protein -
M1E49_RS04785 (958535) 958535..958708 - 174 WP_000028424.1 hypothetical protein Antitoxin
M1E49_RS04790 (958698) 958698..958949 - 252 WP_001065064.1 DUF1024 family protein Toxin
M1E49_RS04795 (958963) 958963..959205 - 243 WP_000131366.1 SAV1978 family virulence-associated passenger protein -
M1E49_RS04800 (959209) 959209..959577 - 369 WP_000101274.1 SA1788 family PVL leukocidin-associated protein -
M1E49_RS04805 (959590) 959590..959994 - 405 WP_000401969.1 RusA family crossover junction endodeoxyribonuclease -
M1E49_RS04810 (960003) 960003..960221 - 219 WP_000338528.1 hypothetical protein -
M1E49_RS04815 (960228) 960228..961112 - 885 WP_271229964.1 DnaD domain protein -
M1E49_RS04820 (961142) 961142..961612 - 471 WP_029549393.1 single-stranded DNA-binding protein -
M1E49_RS04825 (961613) 961613..962230 - 618 WP_071621397.1 MBL fold metallo-hydrolase -
M1E49_RS04830 (962311) 962311..963231 - 921 WP_000138475.1 recombinase RecT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 929308..978093 48785


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9377.26 Da        Isoelectric Point: 3.7128

>T243038 WP_001065064.1 NZ_CP096272:c958949-958698 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T243038 NZ_OW968347:c4633698-4633441 [Klebsiella oxytoca]
ATGAATCTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCTAAAGGTGGCCGGATCGCGCATATTCGCGATGCATC
AGGCCGCGTAACCTCTGTTGAATGCTATAGCCGCGAAGGGCTCCTGCTCAGCGACTGCACGCTCGCCGTTTTCAAAAAAC
TCAAAACCAAAAAACTCATTAAGTCCGTCAACGGGCAGCCCTACCGTATCAATACCACCGGGCTGAACAACGTTCGCGCT
CAGCTGGACAACCGCTAA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT243038 WP_000028424.1 NZ_CP096272:c958708-958535 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT243038 NZ_OW968347:c4633430-4632879 [Klebsiella oxytoca]
ATGACAAACCATAACTTCACCTTTCACATCACCTCAGAGCGTGATGCTGATGATATTCGCGAAGTTGAAACCCGGGCCTT
CGGCTTTAGCAAAGAGGCCGATCTGGTTGCCGCTTTGCTCAACGATGAAAGTGCTCACCCGAGCTTATCTCTGCTGGCCA
AACATAATGGAAAAGCAGTTGGGCATATTTTGTTCACCCTGGCGACGTTCAAAGGGGAGTCTGACTCTCCGATGATGCAT
ATCCTTGCCCCTCTGGCGGTGGTGCCGGAATACCAGGGCATGGGTGTTGGCGGATTACTTATCCAAAGCGGTATTGAGCA
TCTGAAGGCAATGGGGAGCCTGGCGGTATTCGTTCTGGGACATGCCACTTATTACCCGCGGCATGGCTTTGAACCCTGTG
CCGGAGATAAAGGCTATCCGGCGCCTTATCCCATTCCCGAGGAGCATAAAGCCTGCTGGATGCTGCAGCGGCTTTCGTCC
CGGCCGCTGGGGATAACCGGTCAGATACAGTGCGCCCGGGCGTTAATGAAACCCGAGCACTGGCGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References