Detailed information of TA system TA243034

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 20169..20507
• Replicon: chromosome
• Accession: NZ_CP096272
• Organism: Staphylococcus aureus strain FJ0318

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: M1E49_RS00110
• Protein ID: WP_011447039.1
• Coordinates: 20169..20345 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	20333..20507 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1E49_RS00090	17856..18008	+	153	WP_000654329.1	hypothetical protein	-
M1E49_RS00095	18055..18342	+	288	WP_001040255.1	hypothetical protein	-
M1E49_RS00100	18398..18772	+	375	WP_000340977.1	hypothetical protein	-
M1E49_RS00105	19184..19966	+	783	WP_000034842.1	staphylococcal enterotoxin type P	-
M1E49_RS00110	20169..20345	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	20333..20507	-	175	-	-	Antitoxin
M1E49_RS00120	20557..20811	+	255	WP_000611512.1	phage holin	-
M1E49_RS00125	20823..21578	+	756	WP_000861038.1	CHAP domain-containing protein	-
M1E49_RS00130	21769..22260	+	492	WP_000920038.1	staphylokinase	-
M1E49_RS00135	22911..23246	+	336	Protein_26	SH3 domain-containing protein	-
M1E49_RS00140	23757..24107	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
M1E49_RS00145	24160..24420	-	261	WP_001791826.1	hypothetical protein	-
M1E49_RS00150	24731..24910	-	180	WP_000669791.1	hypothetical protein	-
M1E49_RS00155	25282..25479	-	198	WP_000239610.1	phospholipase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	see / sak / scn	1..24107	24106

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T243034 WP_011447039.1 NZ_CP096272:20169-20345 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T243034 NZ_OW968347:865044-865454 [Klebsiella oxytoca]
GTGGTCCTGTGGCAATCTGATTTACGCATCTCGTGGCGAGCGCAATGGTTCTCACTGTTGATGCACGGCGTGGTGGCGGC
GCTGGTGCTGGTGTTGCCCTGGCCGCTGAGCTATACCCCGCTGTGGCTGATACTGCTGTCGCTGGTGGTGTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCAGACAGGGGGAAATAAAGCTGCTGATTGACTCTCGCCTGCGCTGGCAAAAAGCG
GAGTGGGATATCGTCGGCACCCCGTGGGTAATCAATAGCGGAATGCTGCTGCGCCTGAGAAATACGGAAAACCAACGCAC
TCAGCATCTATGGGTGGCGGCGGATAGCATGGACGCGGGCGAGTGGCGCGATCTGCGTCGGCTGGTGTTACAGAAACCGA
CGCAAGATTAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT243034 NZ_CP096272:c20507-20333 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin