Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 53942..54669 | Replicon | plasmid pVirH39 |
Accession | NZ_CP096231 | ||
Organism | Klebsiella pneumoniae subsp. pneumoniae strain H39 |
Toxin (Protein)
Gene name | higB | Uniprot ID | A0A7W3D9W1 |
Locus tag | M0538_RS26540 | Protein ID | WP_011251285.1 |
Coordinates | 54358..54669 (-) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | M0538_RS26535 | Protein ID | WP_011251286.1 |
Coordinates | 53942..54361 (-) | Length | 140 a.a. |
Genomic Context
Location: 49088..52057 (2970 bp)
Type: Others
Protein ID: WP_004213592.1
Type: Others
Protein ID: WP_004213592.1
Location: 52099..52593 (495 bp)
Type: Others
Protein ID: WP_004213594.1
Type: Others
Protein ID: WP_004213594.1
Location: 52654..52767 (114 bp)
Type: Others
Protein ID: Protein_50
Type: Others
Protein ID: Protein_50
Location: 55446..56143 (698 bp)
Type: Others
Protein ID: WP_223175001.1
Type: Others
Protein ID: WP_223175001.1
Location: 58656..59150 (495 bp)
Type: Others
Protein ID: WP_004212794.1
Type: Others
Protein ID: WP_004212794.1
Location: 52827..53795 (969 bp)
Type: Others
Protein ID: WP_086642568.1
Type: Others
Protein ID: WP_086642568.1
Location: 53942..54361 (420 bp)
Type: Antitoxin
Protein ID: WP_011251286.1
Type: Antitoxin
Protein ID: WP_011251286.1
Location: 54358..54669 (312 bp)
Type: Toxin
Protein ID: WP_011251285.1
Type: Toxin
Protein ID: WP_011251285.1
Location: 54874..55311 (438 bp)
Type: Others
Protein ID: Protein_54
Type: Others
Protein ID: Protein_54
Location: 57529..58179 (651 bp)
Type: Others
Protein ID: WP_068893702.1
Type: Others
Protein ID: WP_068893702.1
Location: 58212..58478 (267 bp)
Type: Others
Protein ID: WP_223175074.1
Type: Others
Protein ID: WP_223175074.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
M0538_RS26515 (M0538_26485) | 49088..52057 | + | 2970 | WP_004213592.1 | Tn3 family transposase | - |
M0538_RS26520 (M0538_26490) | 52099..52593 | + | 495 | WP_004213594.1 | hypothetical protein | - |
M0538_RS26525 (M0538_26495) | 52654..52767 | + | 114 | Protein_50 | Hha/YmoA family nucleoid-associated regulatory protein | - |
M0538_RS26530 (M0538_26500) | 52827..53795 | - | 969 | WP_086642568.1 | IS5 family transposase | - |
M0538_RS26535 (M0538_26505) | 53942..54361 | - | 420 | WP_011251286.1 | helix-turn-helix domain-containing protein | Antitoxin |
M0538_RS26540 (M0538_26510) | 54358..54669 | - | 312 | WP_011251285.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
M0538_RS26545 (M0538_26515) | 54874..55311 | - | 438 | Protein_54 | DDE-type integrase/transposase/recombinase | - |
M0538_RS26550 (M0538_26520) | 55446..56143 | + | 698 | WP_223175001.1 | IS1-like element IS1A family transposase | - |
M0538_RS26555 (M0538_26525) | 57529..58179 | - | 651 | WP_068893702.1 | DUF1173 family protein | - |
M0538_RS26560 (M0538_26530) | 58212..58478 | - | 267 | WP_223175074.1 | DUF1173 family protein | - |
M0538_RS26565 (M0538_26535) | 58656..59150 | + | 495 | WP_004212794.1 | thermonuclease family protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Mobilizable plasmid | - | iroB / iroC / iroD / iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA / pla | 1..229037 | 229037 | |
- | inside | IScluster/Tn | - | - | 48528..61336 | 12808 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12346.12 Da Isoelectric Point: 9.7248
>T242910 WP_011251285.1 NZ_CP096231:c54669-54358 [Klebsiella pneumoniae subsp. pneumoniae]
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
Download Length: 312 bp
>T242910 NZ_OW968011:c2073616-2073209 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 140 a.a. Molecular weight: 15377.46 Da Isoelectric Point: 4.4420
>AT242910 WP_011251286.1 NZ_CP096231:c54361-53942 [Klebsiella pneumoniae subsp. pneumoniae]
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
Download Length: 420 bp
>AT242910 NZ_OW968011:c2073863-2073597 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
Structures
Toxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7W3D9W1 |
Antitoxin
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Source | ID | Structure |
---|---|---|
No matching records found |