Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 53942..54669 Replicon plasmid pVirH39
Accession NZ_CP096231
Organism Klebsiella pneumoniae subsp. pneumoniae strain H39

Toxin (Protein)


Gene name higB Uniprot ID A0A7W3D9W1
Locus tag M0538_RS26540 Protein ID WP_011251285.1
Coordinates 54358..54669 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M0538_RS26535 Protein ID WP_011251286.1
Coordinates 53942..54361 (-) Length 140 a.a.

Genomic Context


M0538_RS26515M0538_RS26520M0538_RS26525M0538_RS26550M0538_RS26565M0538_RS26530M0538_RS26535M0538_RS26540M0538_RS26545M0538_RS26555M0538_RS26560
Location: 49088..52057 (2970 bp)
Type: Others
Protein ID: WP_004213592.1
Location: 52099..52593 (495 bp)
Type: Others
Protein ID: WP_004213594.1
Location: 52654..52767 (114 bp)
Type: Others
Protein ID: Protein_50
Location: 55446..56143 (698 bp)
Type: Others
Protein ID: WP_223175001.1
Location: 58656..59150 (495 bp)
Type: Others
Protein ID: WP_004212794.1
Location: 52827..53795 (969 bp)
Type: Others
Protein ID: WP_086642568.1
Location: 53942..54361 (420 bp)
Type: Antitoxin
Protein ID: WP_011251286.1
Location: 54358..54669 (312 bp)
Type: Toxin
Protein ID: WP_011251285.1
Location: 54874..55311 (438 bp)
Type: Others
Protein ID: Protein_54
Location: 57529..58179 (651 bp)
Type: Others
Protein ID: WP_068893702.1
Location: 58212..58478 (267 bp)
Type: Others
Protein ID: WP_223175074.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
M0538_RS26515 (M0538_26485)49088..52057+2970WP_004213592.1Tn3 family transposase-
M0538_RS26520 (M0538_26490)52099..52593+495WP_004213594.1hypothetical protein-
M0538_RS26525 (M0538_26495)52654..52767+114Protein_50Hha/YmoA family nucleoid-associated regulatory protein-
M0538_RS26530 (M0538_26500)52827..53795-969WP_086642568.1IS5 family transposase-
M0538_RS26535 (M0538_26505)53942..54361-420WP_011251286.1helix-turn-helix domain-containing proteinAntitoxin
M0538_RS26540 (M0538_26510)54358..54669-312WP_011251285.1type II toxin-antitoxin system HigB family toxinToxin
M0538_RS26545 (M0538_26515)54874..55311-438Protein_54DDE-type integrase/transposase/recombinase-
M0538_RS26550 (M0538_26520)55446..56143+698WP_223175001.1IS1-like element IS1A family transposase-
M0538_RS26555 (M0538_26525)57529..58179-651WP_068893702.1DUF1173 family protein-
M0538_RS26560 (M0538_26530)58212..58478-267WP_223175074.1DUF1173 family protein-
M0538_RS26565 (M0538_26535)58656..59150+495WP_004212794.1thermonuclease family protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideMobilizable plasmid-iroB / iroC / iroD / iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA / pla1..229037229037
-insideIScluster/Tn--48528..6133612808


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 104 a.a.        Molecular weight: 12346.12 Da        Isoelectric Point: 9.7248

>T242910 WP_011251285.1 NZ_CP096231:c54669-54358 [Klebsiella pneumoniae subsp. pneumoniae]
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE

Download         Length: 312 bp

>T242910 NZ_OW968011:c2073616-2073209 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15377.46 Da        Isoelectric Point: 4.4420

>AT242910 WP_011251286.1 NZ_CP096231:c54361-53942 [Klebsiella pneumoniae subsp. pneumoniae]
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL

Download         Length: 420 bp

>AT242910 NZ_OW968011:c2073863-2073597 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A7W3D9W1


Antitoxin

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Source
ID
Structure
No matching records found

References