Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1496339..1496931 Replicon chromosome
Accession NZ_CP096205
Organism Flavobacterium azooxidireducens strain IGB 4-14

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag M0M57_RS06575 Protein ID WP_248436392.1
Coordinates 1496650..1496931 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M0M57_RS06570 Protein ID WP_248436391.1
Coordinates 1496339..1496638 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M0M57_RS06550 (M0M57_06550) 1493534..1494472 + 939 WP_248436388.1 type IX secretion system membrane protein PorP/SprF -
M0M57_RS06555 (M0M57_06555) 1494482..1494841 + 360 WP_248436389.1 dihydroneopterin aldolase -
M0M57_RS06565 (M0M57_06565) 1495661..1496320 - 660 WP_248436390.1 GldM family protein -
M0M57_RS06570 (M0M57_06570) 1496339..1496638 - 300 WP_248436391.1 HigA family addiction module antitoxin Antitoxin
M0M57_RS06575 (M0M57_06575) 1496650..1496931 - 282 WP_248436392.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M0M57_RS06580 (M0M57_06580) 1496995..1497678 - 684 WP_248436393.1 LysE family transporter -
M0M57_RS06585 (M0M57_06585) 1497764..1498432 - 669 WP_248436394.1 head GIN domain-containing protein -
M0M57_RS06590 (M0M57_06590) 1498486..1498737 - 252 WP_248436395.1 hypothetical protein -
M0M57_RS06595 (M0M57_06595) 1498796..1500973 - 2178 WP_248436396.1 ribonuclease R -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-79)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11050.67 Da        Isoelectric Point: 10.2059

>T242866 WP_248436392.1 NZ_CP096205:c1496931-1496650 [Flavobacterium azooxidireducens]
VIKSFTCKETEKIWNGIQSRKLPSDIQNVARRKLRMINNAQNINDLRIPPANHLEKLSGNLEGFHSIRINKQWRIIFRWE
NDNALEVEIIDYH

Download         Length: 282 bp

>T242866 NZ_OW967966:c4334441-4334154 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGTATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11379.06 Da        Isoelectric Point: 5.1974

>AT242866 WP_248436391.1 NZ_CP096205:c1496638-1496339 [Flavobacterium azooxidireducens]
MATLKNIHPGEILKEEFLVPLEISAYRLSKETFIPQTRISEIIKGNRRITADTALRLSKYFSTTAKFWLGLQDDYDIEEE
KMAKKTELDSIQPMNTDAA

Download         Length: 300 bp

>AT242866 NZ_OW967966:c4334167-4333865 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References