Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 18405..19056 Replicon plasmid pJNE5-64k
Accession NZ_CP096122
Organism Acinetobacter portensis strain JNE5

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MZO21_RS14530 Protein ID WP_092818271.1
Coordinates 18700..19056 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MZO21_RS14525 Protein ID WP_092818272.1
Coordinates 18405..18707 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MZO21_RS14500 (MZO21_14495) 13533..13835 - 303 WP_000286964.1 type II toxin-antitoxin system RelE/ParE family toxin -
MZO21_RS14505 (MZO21_14500) 13958..15272 - 1315 Protein_15 ISNCY family transposase -
MZO21_RS14510 (MZO21_14505) 15564..15767 + 204 WP_067731914.1 hypothetical protein -
MZO21_RS14515 (MZO21_14510) 16033..18003 + 1971 WP_248103958.1 choline BCCT transporter BetT -
MZO21_RS14520 (MZO21_14515) 18156..18284 - 129 Protein_18 IS3 family transposase -
MZO21_RS14525 (MZO21_14520) 18405..18707 - 303 WP_092818272.1 XRE family transcriptional regulator Antitoxin
MZO21_RS14530 (MZO21_14525) 18700..19056 - 357 WP_092818271.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MZO21_RS14535 (MZO21_14530) 19638..20528 - 891 WP_248103956.1 LysR family transcriptional regulator -
MZO21_RS14540 (MZO21_14535) 20678..21271 + 594 WP_248103953.1 NAD(P)H-dependent oxidoreductase -
MZO21_RS14545 (MZO21_14540) 21281..21595 + 315 WP_248103960.1 putative quinol monooxygenase -
MZO21_RS14550 (MZO21_14545) 21775..22926 + 1152 WP_248104258.1 IS4 family transposase -
MZO21_RS14555 (MZO21_14550) 22963..23256 - 294 WP_248103949.1 type II toxin-antitoxin system RelE/ParE family toxin -
MZO21_RS14560 (MZO21_14555) 23246..23491 - 246 WP_000246756.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..64629 64629
- inside IScluster/Tn - - 5719..15284 9565


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-81)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13501.46 Da        Isoelectric Point: 6.4623

>T242776 WP_092818271.1 NZ_CP096122:c19056-18700 [Acinetobacter portensis]
MWTVITTDLFNQWLEQQDESTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIADKGGKKRFYTEMLAIADQQYELHLSTLGEQSNG

Download         Length: 357 bp

>T242776 NZ_OW967374:2220885-2220988 [Klebsiella oxytoca]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTTTTTTT

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11254.05 Da        Isoelectric Point: 6.4759

>AT242776 WP_092818272.1 NZ_CP096122:c18707-18405 [Acinetobacter portensis]
MAKTLQELLANRSPESQARIQKMADELLLENQLHLIREELEISQKELAETLGIKQPSLSAIENRGNDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp

>AT242776 NZ_OW967374:c2220995-2220850 [Klebsiella oxytoca]
AAAAGATAAAAAAAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCCTTATAAGAATAGTTTACCGTGTCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References