Detailed information of TA system TA242744

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2483514..2483698
• Replicon: chromosome
• Accession: NZ_CP096114
• Organism: Staphylococcus argenteus strain MRSA-139-14-168

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: M0D62_RS12180
• Protein ID: WP_000482650.1
• Coordinates: 2483591..2483698 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2483514..2483574 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M0D62_RS12170 (M0D62_12160)	2479367..2481100	-	1734	WP_047435654.1	ABC transporter ATP-binding protein	-
M0D62_RS12175 (M0D62_12165)	2481125..2482888	-	1764	WP_047435657.1	ABC transporter ATP-binding protein	-
-	2483514..2483574	+	61	-	-	Antitoxin
M0D62_RS12180 (M0D62_12170)	2483591..2483698	-	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
M0D62_RS12185 (M0D62_12175)	2483832..2484218	-	387	WP_000779346.1	flippase GtxA	-
M0D62_RS12190 (M0D62_12180)	2484486..2485628	+	1143	WP_047431353.1	glycerate kinase	-
M0D62_RS12195 (M0D62_12185)	2485687..2486346	+	660	WP_000831306.1	membrane protein	-
M0D62_RS12200 (M0D62_12190)	2486531..2487742	+	1212	WP_047435663.1	multidrug effflux MFS transporter	-
M0D62_RS12205 (M0D62_12195)	2487858..2488337	-	480	WP_047435666.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T242744 WP_000482650.1 NZ_CP096114:c2483698-2483591 [Staphylococcus argenteus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T242744 NZ_OW967178:1116622-1116933 [Escherichia coli]
ATGCACATCATTTCGAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTACACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCTAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT242744 NZ_CP096114:2483514-2483574 [Staphylococcus argenteus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCGCTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin