Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2230124..2230719 Replicon chromosome
Accession NZ_CP096018
Organism Alkalimarinus coralli strain SCSIO 12817

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MY525_RS10040 Protein ID WP_250655738.1
Coordinates 2230124..2230414 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MY525_RS10045 Protein ID WP_250655739.1
Coordinates 2230429..2230719 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MY525_RS10030 2225626..2227896 - 2271 WP_250655737.1 phosphoenolpyruvate--protein phosphotransferase -
MY525_RS10035 2228070..2229248 + 1179 WP_250658837.1 tryptophan synthase subunit beta -
MY525_RS10040 2230124..2230414 + 291 WP_250655738.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MY525_RS10045 2230429..2230719 + 291 WP_250655739.1 HigA family addiction module antitoxin Antitoxin
MY525_RS10050 2230966..2232282 - 1317 WP_250655740.1 sphingomyelin phosphodiesterase -
MY525_RS10055 2232588..2233652 - 1065 WP_250655741.1 transposase -
MY525_RS10060 2233674..2234090 + 417 WP_250655742.1 IS200/IS605 family transposase -
MY525_RS10065 2234176..2234856 - 681 WP_250655743.1 energy-coupling factor ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(23-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-69)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11028.51 Da        Isoelectric Point: 7.4018

>T242715 WP_250655738.1 NZ_CP096018:2230124-2230414 [Alkalimarinus coralli]
MIISFGNKATSDLFNGVSSRWVRKLPNQIHELALYKLDVINAAQNLDDLKSPPGNRLELLKGDLEGFHSIRINSQWRIVF
RWDSNAAHDVQIVDYH

Download         Length: 291 bp

>T242715 NZ_OW849528:161273-161581 [Citrobacter freundii]
ATGCAATATACCGTTTACCGCAATCCCGGCAACAGCCAGGCATACCCTTACCTGCTGGATATACAGAGCGACATCATTGG
CGAGTTAAATACCCGCCTGGTGATCCCCCTTCATCGGCTTAAAAAAGGAGCCTCGGCCCCGGTTGCGCGATTAACTCCGG
TCATACAGGTGGAAGGGAATGACGTTATCCTGATGACGCATGAAATGGCTTCAGTCCGCGTGAAGCAGCTCGGTCAGGCG
GTCATGGACGCATCTCCGTTCCGGCACACTATCAAAAGTGCGGTGGACTTCCTGCTGGATGGTTTCTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10646.34 Da        Isoelectric Point: 6.8790

>AT242715 WP_250655739.1 NZ_CP096018:2230429-2230719 [Alkalimarinus coralli]
MIPSNRIATHPGVILLKEFLEPLEVTQKALALHLGVPVQRINEIVRGKRGVTPETAWLLSESLNTSPEFWLNLQSIHDLS
ANRPENHIQPLVAAGI

Download         Length: 291 bp

>AT242715 NZ_OW849528:161031-161270 [Citrobacter freundii]
ATGCAGGCTACAGCTGCTCGCCAGAAAAAAACCGTCAGTGTCACCCTTGAGCCAATGCTCGTACAGCAGGCAAAAGACGC
TGGGATTAACTTGTCCGCCACGCTGGCAGAAGCGCTTCAGAGCAAACTGAAGGCCAGTGCAGCGGAAGAATGGAAACGAC
AGAATCGTGCTGGTATTCAGGAGTTGAACCGCATCACTGAAGAGCATGGGTTACTGTCTGACGAATACAGGACGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References