Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2229826..2230421 Replicon chromosome
Accession NZ_CP096017
Organism Alkalimarinus coralli strain SCSIO 12638

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MY524_RS10030 Protein ID WP_250655738.1
Coordinates 2229826..2230116 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MY524_RS10035 Protein ID WP_250655739.1
Coordinates 2230131..2230421 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MY524_RS10020 2225328..2227598 - 2271 WP_250655737.1 phosphoenolpyruvate--protein phosphotransferase -
MY524_RS10025 2227772..2228950 + 1179 WP_250658837.1 tryptophan synthase subunit beta -
MY524_RS10030 2229826..2230116 + 291 WP_250655738.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MY524_RS10035 2230131..2230421 + 291 WP_250655739.1 HigA family addiction module antitoxin Antitoxin
MY524_RS10040 2230668..2231984 - 1317 WP_250655740.1 sphingomyelin phosphodiesterase -
MY524_RS10045 2232290..2233354 - 1065 WP_250655741.1 transposase -
MY524_RS10050 2233376..2233792 + 417 WP_250655742.1 IS200/IS605 family transposase -
MY524_RS10055 2233878..2234558 - 681 WP_250655743.1 energy-coupling factor ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(23-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-69)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11028.51 Da        Isoelectric Point: 7.4018

>T242704 WP_250655738.1 NZ_CP096017:2229826-2230116 [Alkalimarinus coralli]
MIISFGNKATSDLFNGVSSRWVRKLPNQIHELALYKLDVINAAQNLDDLKSPPGNRLELLKGDLEGFHSIRINSQWRIVF
RWDSNAAHDVQIVDYH

Download         Length: 291 bp

>T242704 NZ_OW849471:188966-189382 [Klebsiella oxytoca]
ATGACCAAAACCTACATGCTGGATACTAATATCTGCTCTTATATCATGCGCGAACAACCGGAAGCGGTGCTGAAACGCCT
AGAGCAAGCGGTGTTGCGCCGTCACCGGATAGTGGTGTCAGCCATCACCTATGCCGAAATGCGTTTTGGTGCCATCGGTA
AAAGGGCTTCGCCCCGTCATGTGCAGCTGGTGGACGCATTCTGTGCGCGCCTTGATGCCATACTGGCTTGGGATCGGGCC
GCAGTTGACGCTACAACAGAGGTTAAGGCCACGCTAGCAGCTGCCGGCACGCCAATCGGCCCAAACGACACAGCCATTGC
TGGACATGCCATTGCCGCTGGCGCCATCCTGGTGACGAATAATACGCGTGAATTTGAGCGAGTCGCTGGTCTGACGTTTG
AAGACTGGGTGCAATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10646.34 Da        Isoelectric Point: 6.8790

>AT242704 WP_250655739.1 NZ_CP096017:2230131-2230421 [Alkalimarinus coralli]
MIPSNRIATHPGVILLKEFLEPLEVTQKALALHLGVPVQRINEIVRGKRGVTPETAWLLSESLNTSPEFWLNLQSIHDLS
ANRPENHIQPLVAAGI

Download         Length: 291 bp

>AT242704 NZ_OW849471:188739-188969 [Klebsiella oxytoca]
ATGCGAACTGTATCTGTATTCAGGAACGGTAATAACCGGGCCATCCGTCTGCCCCGCGATCTGGACTTTGACGGCGTGAA
CGAACTGGAAATCATCCGCGAGGGCGATACCCTCATCCTGCGGCCGGTAAAACCCAGTTGGAGTTCGTTCCGCCAGGAGG
AAAAAGCTGACGCAGATTTTATGGCGGAGCGTGAAAATGTTGTTAGTGACGAGGGACGTTTTGAGCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References