Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2184212..2184905 Replicon chromosome
Accession NZ_CP095856
Organism Escherichia coli strain EC6563

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag MYG04_RS10580 Protein ID WP_000415584.1
Coordinates 2184609..2184905 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag MYG04_RS10575 Protein ID WP_000650107.1
Coordinates 2184212..2184607 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYG04_RS10565 (2180076) 2180076..2182334 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
MYG04_RS10570 (2182472) 2182472..2184079 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
MYG04_RS10575 (2184212) 2184212..2184607 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
MYG04_RS10580 (2184609) 2184609..2184905 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
MYG04_RS10585 (2185110) 2185110..2185592 - 483 WP_000183505.1 GyrI-like domain-containing protein -
MYG04_RS10590 (2185645) 2185645..2186037 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
MYG04_RS10595 (2186189) 2186189..2186848 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
MYG04_RS10600 (2186845) 2186845..2188194 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
MYG04_RS10605 (2188240) 2188240..2188572 - 333 WP_000917684.1 DUF2645 family protein -
MYG04_RS10610 (2188891) 2188891..2189472 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
MYG04_RS10615 (2189503) 2189503..2189817 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T242642 WP_000415584.1 NZ_CP095856:c2184905-2184609 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T242642 NZ_OW849082:906320-906727 [Citrobacter freundii]
GTGGTCCAGTGGCAATCTGATTTACGCGTATCATGGCGCGCGCAGTGGCTTTCACTGCTAATTCATGGGCTGGTCGCGGT
GTTTATTTTATTGATGCCCTGGCCATTGAGCTACACCCCATTATGGCTGGTTTTGCTCTCTCTGGTGGTATTCGATAGCG
TTCGCAGTCAGCGTCGAATCAACGCCTGTCAGGGTGAGATTCGGCTGTTGATGGATGGCCGTCTGCGCTGGCAAGGGCAA
GAGTGGTCTATCGTTAGCGCCCCCTGGATGGTTAAAACAGGCATGATGCTGCGTTTGCGCTCTGATGCCGGAAAACGTCA
ACATTTGTGGCTGGCGGCAGACAGTATGGATGATGCTGAGTGGCGGGATTTACGGCGGTTGATGCTGCAAAAGGCGAAGC
AGAAGTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT242642 WP_000650107.1 NZ_CP095856:c2184607-2184212 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT242642 NZ_OW849082:906073-906339 [Citrobacter freundii]
ATGGATATTAACAACAAAGCACGTATTCATTGGGCATGCCGCCGAGGTATGCGCGAGCTGGATATCTCGATCATGCCGTT
TTTCGAACATGAATATGACAGCTTAAGTGACGAAGAAAAACGTATCTTTATCCGTCTGCTAGAATGTGATGATCCAGATT
TATTTAACTGGTTGATGAATCATGGGAAACCAGCTGATGCTGAGCTGGAGCAGATGGTGCGACTTATCCAGACACGGAAT
CGGGAACGTGGTCCAGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References