Detailed information of TA system TA242617

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3656438..3656696
• Replicon: chromosome
• Accession: NZ_CP095843
• Organism: Escherichia fergusonii strain EF21QZZ116

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: MYF53_RS17880
• Protein ID: WP_220469022.1
• Coordinates: 3656438..3656590 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	3656639..3656696 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MYF53_RS17860	3651504..3652091	+	588	WP_002431696.1	molybdopterin adenylyltransferase	-
MYF53_RS17865	3652125..3652691	-	567	WP_000528529.1	acetate uptake transporter	-
MYF53_RS17870	3653199..3655115	+	1917	WP_000516135.1	molecular chaperone DnaK	-
MYF53_RS17875	3655204..3656334	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
MYF53_RS17880	3656438..3656590	-	153	WP_220469022.1	type I toxin-antitoxin system toxin MokC	Toxin
-	3656639..3656696	+	58	-	-	Antitoxin
MYF53_RS17885	3657131..3658297	+	1167	WP_000681374.1	Na+/H+ antiporter NhaA	-
MYF53_RS17890	3658365..3659264	+	900	WP_000019050.1	transcriptional activator NhaR	-
MYF53_RS17895	3659360..3659623	-	264	WP_001274021.1	30S ribosomal protein S20	-
MYF53_RS17900	3659726..3659944	+	219	WP_001353471.1	DUF2575 family protein	-
MYF53_RS17905	3659952..3660893	+	942	WP_000767329.1	bifunctional riboflavin kinase/FAD synthetase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5561.66 Da
• Isoelectric Point: 7.1312

>T242617 WP_220469022.1 NZ_CP095843:c3656590-3656438 [Escherichia fergusonii]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYEFE

Nucleotide

• Length: 153 bp

>T242617 NZ_OW849064:2394898-2395275 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT242617 NZ_CP095843:3656639-3656696 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin