Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3570138..3570937 Replicon chromosome
Accession NZ_CP095843
Organism Escherichia fergusonii strain EF21QZZ116

Toxin (Protein)


Gene name yhaV Uniprot ID F0JQM9
Locus tag MYF53_RS17410 Protein ID WP_000347270.1
Coordinates 3570138..3570602 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID B7LMV4
Locus tag MYF53_RS17415 Protein ID WP_015953962.1
Coordinates 3570602..3570937 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYF53_RS17380 (3565139) 3565139..3565573 - 435 WP_000948832.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
MYF53_RS17385 (3565591) 3565591..3566469 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
MYF53_RS17390 (3566459) 3566459..3567238 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
MYF53_RS17395 (3567249) 3567249..3567722 - 474 WP_024256997.1 PTS N-acetylgalactosamine transporter subunit IIB -
MYF53_RS17400 (3567745) 3567745..3569025 - 1281 WP_182245402.1 tagatose-bisphosphate aldolase subunit KbaZ -
MYF53_RS17405 (3569274) 3569274..3570083 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
MYF53_RS17410 (3570138) 3570138..3570602 - 465 WP_000347270.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
MYF53_RS17415 (3570602) 3570602..3570937 - 336 WP_015953962.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
MYF53_RS17420 (3571086) 3571086..3572657 - 1572 WP_249895991.1 galactarate dehydratase -
MYF53_RS17425 (3573128) 3573128..3573898 + 771 WP_222702010.1 2-dehydro-3-deoxyglucarate aldolase -
MYF53_RS17430 (3573923) 3573923..3574813 + 891 WP_000178100.1 2-hydroxy-3-oxopropionate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17806.22 Da        Isoelectric Point: 9.6924

>T242616 WP_000347270.1 NZ_CP095843:c3570602-3570138 [Escherichia fergusonii]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEEAH

Download         Length: 465 bp

>T242616 NZ_OW849064:c2248512-2248105 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12281.89 Da        Isoelectric Point: 4.4128

>AT242616 WP_015953962.1 NZ_CP095843:c3570937-3570602 [Escherichia fergusonii]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDPTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT242616 NZ_OW849064:c2248759-2248493 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCACCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NQ90

Antitoxin

Source ID Structure
AlphaFold DB B7LMV4

References