Detailed information of TA system TA242577

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3385304..3385562
• Replicon: chromosome
• Accession: NZ_CP095786
• Organism: Escherichia fergusonii strain EF21JD053

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: MYB88_RS16180
• Protein ID: WP_000809168.1
• Coordinates: 3385304..3385456 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	3385505..3385562 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MYB88_RS16160	3380370..3380957	+	588	WP_002431696.1	molybdopterin adenylyltransferase	-
MYB88_RS16165	3380991..3381557	-	567	WP_000528529.1	acetate uptake transporter	-
MYB88_RS16170	3382065..3383981	+	1917	WP_000516135.1	molecular chaperone DnaK	-
MYB88_RS16175	3384070..3385200	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
MYB88_RS16180	3385304..3385456	-	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
-	3385505..3385562	+	58	-	-	Antitoxin
MYB88_RS16185	3385997..3387163	+	1167	WP_000681374.1	Na+/H+ antiporter NhaA	-
MYB88_RS16190	3387231..3388130	+	900	WP_000019049.1	transcriptional activator NhaR	-
MYB88_RS16195	3388226..3388489	-	264	WP_001274021.1	30S ribosomal protein S20	-
MYB88_RS16200	3388592..3388810	+	219	WP_097343043.1	DUF2575 family protein	-
MYB88_RS16205	3388818..3389759	+	942	WP_042021512.1	bifunctional riboflavin kinase/FAD synthetase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T242577 WP_000809168.1 NZ_CP095786:c3385456-3385304 [Escherichia fergusonii]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T242577 NZ_OW848788:2193879-2193982 [Citrobacter freundii]
GGCAGGGTAACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Nucleotide

• Length: 58 bp

>AT242577 NZ_CP095786:3385505-3385562 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin