Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3300071..3300870 Replicon chromosome
Accession NZ_CP095786
Organism Escherichia fergusonii strain EF21JD053

Toxin (Protein)


Gene name yhaV Uniprot ID F0JQM9
Locus tag MYB88_RS15720 Protein ID WP_000347270.1
Coordinates 3300071..3300535 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID B7LMV4
Locus tag MYB88_RS15725 Protein ID WP_015953962.1
Coordinates 3300535..3300870 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYB88_RS15690 (3295073) 3295073..3295507 - 435 WP_000948832.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
MYB88_RS15695 (3295525) 3295525..3296403 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
MYB88_RS15700 (3296393) 3296393..3297172 - 780 WP_223684419.1 PTS N-acetylgalactosamine transporter subunit IIC -
MYB88_RS15705 (3297183) 3297183..3297656 - 474 WP_032303829.1 PTS N-acetylgalactosamine transporter subunit IIB -
MYB88_RS15710 (3297679) 3297679..3298959 - 1281 WP_223684406.1 tagatose-bisphosphate aldolase subunit KbaZ -
MYB88_RS15715 (3299207) 3299207..3300016 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
MYB88_RS15720 (3300071) 3300071..3300535 - 465 WP_000347270.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
MYB88_RS15725 (3300535) 3300535..3300870 - 336 WP_015953962.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
MYB88_RS15730 (3301019) 3301019..3302590 - 1572 WP_223684407.1 galactarate dehydratase -
MYB88_RS15735 (3303061) 3303061..3303831 + 771 WP_001058567.1 2-dehydro-3-deoxyglucarate aldolase -
MYB88_RS15740 (3303856) 3303856..3304746 + 891 WP_223684408.1 2-hydroxy-3-oxopropionate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17806.22 Da        Isoelectric Point: 9.6924

>T242576 WP_000347270.1 NZ_CP095786:c3300535-3300071 [Escherichia fergusonii]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEEAH

Download         Length: 465 bp

>T242576 NZ_OW848788:c1105476-1105069 [Citrobacter freundii]
GTGGTCCAGTGGCAATCTGATTTACGCGTATCATGGCGCGCGCAGTGGCTTTCACTGCTAATTCATGGGCTGGTCGCGGT
GTTTATTTTATTGATGCCCTGGCCATTGAGCTACACCCCATTATGGCTGGTTTTGCTCTCTCTGGTGGTATTCGATAGCG
TTCGCAGTCAGCGTCGAATCAACGCCTGTCAGGGTGAGATTAGGTTGTTGATGGATGGCCGTCTGCGCTGGCAAGGGCAA
GAGTGGTCTATCGTTAGCGCCCCCTGGATGGTTAAAACAGGCATGATGCTGCGTTTGCGCTCTGATGCCGGAAAACGTCA
ACATTTGTGGCTGGCGGCAGACAGTATGGATGATGCAGAGTGGCGGGATTTACGGCGGTTGATGCTGCAAAAGGCGAAGC
AGAAGTAG

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12281.89 Da        Isoelectric Point: 4.4128

>AT242576 WP_015953962.1 NZ_CP095786:c3300870-3300535 [Escherichia fergusonii]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDPTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT242576 NZ_OW848788:c1105723-1105457 [Citrobacter freundii]
ATGGATATTAACAACAAAGCACGTATTCATTGGGCATGCCGCCGCGGTATGCGCGAGCTGGACATCTCGATCATGCCGTT
TTTCGAACATGAATATGACAGCTTAAGTGACGAAGAAAAACGTATCTTTATCCGTCTGCTAGAATGTGATGATCCAGATT
TATTTAACTGGTTGATGAATCATGGGAAACCAGCTGATGCTGAGCTGGAGCAGATGGTGCGACTTATCCAGACACGGAAT
CGGGAACGTGGTCCAGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NQ90

Antitoxin

Source ID Structure
AlphaFold DB B7LMV4

References