Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 479227..479789 Replicon chromosome
Accession NZ_CP095786
Organism Escherichia fergusonii strain EF21JD053

Toxin (Protein)


Gene name higB Uniprot ID E9XKD5
Locus tag MYB88_RS02370 Protein ID WP_000605673.1
Coordinates 479511..479789 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag MYB88_RS02365 Protein ID WP_000781370.1
Coordinates 479227..479511 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYB88_RS02350 (474586) 474586..477633 + 3048 WP_015912497.1 formate dehydrogenase-N subunit alpha -
MYB88_RS02355 (477646) 477646..478530 + 885 WP_001240580.1 formate dehydrogenase N subunit beta -
MYB88_RS02360 (478523) 478523..479176 + 654 WP_000045645.1 formate dehydrogenase-N subunit gamma -
MYB88_RS02365 (479227) 479227..479511 - 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
MYB88_RS02370 (479511) 479511..479789 - 279 WP_000605673.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MYB88_RS02375 (479975) 479975..480985 - 1011 WP_000642407.1 alcohol dehydrogenase AdhP -
MYB88_RS02380 (481120) 481120..482817 - 1698 WP_046082348.1 malate dehydrogenase -
MYB88_RS02385 (482974) 482974..483111 - 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
MYB88_RS02390 (483213) 483213..483428 - 216 WP_000495766.1 biofilm-dependent modulation protein -
MYB88_RS02395 (483772) 483772..484203 + 432 WP_000152305.1 peroxiredoxin OsmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10535.13 Da        Isoelectric Point: 7.3562

>T242562 WP_000605673.1 NZ_CP095786:c479789-479511 [Escherichia fergusonii]
MIMNFRHKGLRDLFLLGKTSGVIPTQIKRLRHRLAVIDAASCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T242562 NZ_OW848785:3465757-3466134 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT242562 WP_000781370.1 NZ_CP095786:c479511-479227 [Escherichia fergusonii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT242562 NZ_OW848785:3465299-3465667 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0L7ADF6

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References