Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 13609..14266 | Replicon | plasmid p363Kb |
| Accession | NZ_CP095777 | ||
| Organism | Klebsiella pneumoniae strain bo714 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | MX575_RS26465 | Protein ID | WP_000270043.1 |
| Coordinates | 13916..14266 (-) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | MX575_RS26460 | Protein ID | WP_000124640.1 |
| Coordinates | 13609..13911 (-) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MX575_RS26415 (MX575_26415) | 9234..9662 | + | 429 | WP_000591074.1 | hypothetical protein | - |
| MX575_RS26420 (MX575_26420) | 9719..10078 | + | 360 | WP_000422768.1 | hypothetical protein | - |
| MX575_RS26425 (MX575_26425) | 10078..10524 | + | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
| MX575_RS26430 (MX575_26430) | 10521..11039 | + | 519 | WP_000210756.1 | nitrite reductase | - |
| MX575_RS26435 (MX575_26435) | 11039..11269 | + | 231 | WP_000972663.1 | hypothetical protein | - |
| MX575_RS26440 (MX575_26440) | 11256..12113 | + | 858 | WP_001167032.1 | hypothetical protein | - |
| MX575_RS26445 (MX575_26445) | 12344..12871 | + | 528 | WP_001236377.1 | thermonuclease family protein | - |
| MX575_RS26450 (MX575_26450) | 12929..13201 | + | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| MX575_RS26455 (MX575_26455) | 13289..13582 | + | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| MX575_RS26460 (MX575_26460) | 13609..13911 | - | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| MX575_RS26465 (MX575_26465) | 13916..14266 | - | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| MX575_RS26470 (MX575_26470) | 14429..14977 | + | 549 | WP_001061574.1 | transcriptional regulator | - |
| MX575_RS26475 (MX575_26475) | 15318..15512 | + | 195 | WP_000343597.1 | hypothetical protein | - |
| MX575_RS26480 (MX575_26480) | 15523..15894 | + | 372 | WP_000516916.1 | hypothetical protein | - |
| MX575_RS26485 (MX575_26485) | 15887..16357 | + | 471 | WP_001281821.1 | hypothetical protein | - |
| MX575_RS26490 (MX575_26490) | 16372..16707 | - | 336 | WP_000683476.1 | hypothetical protein | - |
| MX575_RS26495 (MX575_26495) | 16804..17292 | + | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| MX575_RS26500 (MX575_26500) | 17295..17792 | + | 498 | WP_000062185.1 | hypothetical protein | - |
| MX575_RS26505 (MX575_26505) | 18007..18711 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| MX575_RS26510 (MX575_26510) | 19018..19197 | + | 180 | Protein_31 | helix-turn-helix domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | floR / tet(A) / aph(6)-Id / aph(3'')-Ib / aph(3')-VIb / sul2 / blaCMY-16 / aph(3')-Ia / aac(6')-Ib / catA1 / dfrA14 / ARR-3 / cmlA1 / blaOXA-10 / ant(3'')-Ia / qacE / sul1 | - | 1..363560 | 363560 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13328.21 Da Isoelectric Point: 5.2421
>T242551 WP_000270043.1 NZ_CP095777:c14266-13916 [Klebsiella pneumoniae]
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
Download Length: 351 bp
>T242551 NZ_OW848785:c1709786-1709379 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11006.73 Da Isoelectric Point: 7.2036
>AT242551 WP_000124640.1 NZ_CP095777:c13911-13609 [Klebsiella pneumoniae]
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
Download Length: 303 bp
>AT242551 NZ_OW848785:c1710033-1709767 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCACCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCACCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|