242525

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 774121..774716 Replicon chromosome
Accession NZ_CP095774
Organism Pseudomonas aeruginosa strain 34Pae8

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag MX625_RS03630 Protein ID WP_003113526.1
Coordinates 774121..774399 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MX625_RS03635 Protein ID WP_003133769.1
Coordinates 774411..774716 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MX625_RS03610 769546..770784 + 1239 WP_003095023.1 C69 family dipeptidase -
MX625_RS03615 770846..771493 + 648 WP_003095021.1 carbonate dehydratase -
MX625_RS03620 771564..773792 - 2229 WP_023104079.1 TonB-dependent receptor -
MX625_RS03625 773940..774068 + 129 Protein_717 integrase -
MX625_RS03630 774121..774399 + 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MX625_RS03635 774411..774716 + 306 WP_003133769.1 HigA family addiction module antitoxin Antitoxin
MX625_RS03645 775111..776211 - 1101 WP_003095017.1 redox-regulated ATPase YchF -
MX625_RS03650 776252..776836 - 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
MX625_RS03655 776878..777492 - 615 WP_003095013.1 50S ribosomal protein L25/general stress protein Ctc -
MX625_RS03660 777609..778550 - 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
MX625_RS03670 778717..779565 - 849 WP_003095007.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T242525 WP_003113526.1 NZ_CP095774:774121-774399 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T242525 NZ_OW706648:c2988692-2988291 [Salmonella enterica subsp. enterica serovar Typhi]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCCTTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGACAG
GACTGGACGCTCTTGCGTCCTCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
AG

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11214.73 Da        Isoelectric Point: 4.6081

>AT242525 WP_003133769.1 NZ_CP095774:774411-774716 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp

>AT242525 NZ_OW706648:c2988939-2988673 [Salmonella enterica subsp. enterica serovar Typhi]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References