Detailed information of TA system TA242513

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 4817459..4818063
• Replicon: chromosome
• Accession: NZ_CP095766
• Organism: Pseudomonas chengduensis strain T1624

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: MYO55_RS22450
• Protein ID: WP_045735618.1
• Coordinates: 4817749..4818063 (-)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A328VUT6
• Locus tag: MYO55_RS22445
• Protein ID: WP_021488745.1
• Coordinates: 4817459..4817749 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MYO55_RS22435	4816125..4816754	-	630	WP_247722809.1	hypothetical protein	-
MYO55_RS22440	4816811..4817161	-	351	WP_052716968.1	integrase	-
MYO55_RS22445	4817459..4817749	-	291	WP_021488745.1	helix-turn-helix domain-containing protein	Antitoxin
MYO55_RS22450	4817749..4818063	-	315	WP_045735618.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MYO55_RS22455	4818596..4819366	+	771	WP_045735619.1	nuclease-related domain-containing protein	-
MYO55_RS22460	4819534..4821042	+	1509	WP_175354152.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (43-99)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-72)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11874.73 Da
• Isoelectric Point: 9.7334

>T242513 WP_045735618.1 NZ_CP095766:c4818063-4817749 [Pseudomonas chengduensis]
MIFIETPIFTEDVKELLSDDEYREFQQYLADNPLAGRVITETGGLRKVRWGSAGRGKSGGVRVIYFHVVGASQIRLVMIY
QKGIKDDLSKDEKKALRKIIEGWK

Nucleotide

• Length: 315 bp

>T242513 NZ_OW706512:c2360391-2359990 [Salmonella enterica subsp. enterica serovar Typhi]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCCTTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGACAG
GACTGGACGCTCTTGCGTCCTCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
AG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10792.33 Da
• Isoelectric Point: 10.9144

>AT242513 WP_021488745.1 NZ_CP095766:c4817749-4817459 [Pseudomonas chengduensis]
MEKNLFNRLLESTVQMDEIARGERQPSREFHVDAAQVRIIRKRTGMAQPAFAEAIGVALGTLRNWEQGRRDPEGPAKALL
RAISNDPQNVIAALRQ

Nucleotide

• Length: 291 bp

>AT242513 NZ_OW706512:c2360638-2360372 [Salmonella enterica subsp. enterica serovar Typhi]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A328VUT6