Detailed information of TA system TA242510

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 2936527..2937227
• Replicon: chromosome
• Accession: NZ_CP095766
• Organism: Pseudomonas chengduensis strain T1624

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: MYO55_RS13485
• Protein ID: WP_017676846.1
• Coordinates: 2936931..2937227 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: A0A1H2LFQ3
• Locus tag: MYO55_RS13480
• Protein ID: WP_031306592.1
• Coordinates: 2936527..2936928 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MYO55_RS13460	2931985..2933343	-	1359	WP_247722385.1	glutathione-disulfide reductase	-
MYO55_RS13465	2933416..2933838	+	423	WP_247722386.1	VOC family protein	-
MYO55_RS13470	2933975..2934814	-	840	WP_003460169.1	UTP--glucose-1-phosphate uridylyltransferase GalU	-
MYO55_RS13475	2934857..2936218	-	1362	WP_064496018.1	UDP-glucose/GDP-mannose dehydrogenase family protein	-
MYO55_RS13480	2936527..2936928	-	402	WP_031306592.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
MYO55_RS13485	2936931..2937227	-	297	WP_017676846.1	type II toxin-antitoxin system MqsR family toxin	Toxin
MYO55_RS13490	2937703..2938053	-	351	WP_112210043.1	hypothetical protein	-
MYO55_RS13495	2938060..2938563	-	504	WP_112210041.1	hypothetical protein	-
MYO55_RS13500	2938636..2938833	-	198	WP_112210039.1	carbon storage regulator	-
MYO55_RS13505	2938902..2939672	-	771	WP_112210037.1	hypothetical protein	-
MYO55_RS13510	2939707..2940717	-	1011	WP_112210035.1	GTP pyrophosphokinase	-
MYO55_RS13515	2940773..2941048	-	276	WP_071557459.1	helix-turn-helix transcriptional regulator	-
MYO55_RS13520	2941176..2941364	+	189	WP_112210033.1	DNA-binding protein	-
MYO55_RS13530	2941721..2941939	-	219	WP_112210030.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-97)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11402.19 Da
• Isoelectric Point: 7.2011

>T242510 WP_017676846.1 NZ_CP095766:c2937227-2936931 [Pseudomonas chengduensis]
MEKRKPHFKLELVKQAVTEQRYRFTRVALEGGAELGMEMADMLAVISALSSRDFFKSMTTYADHTTWQDVYRPDTEFGQV
YLKFTLVADLLIVSFKEK

Nucleotide

• Length: 297 bp

>T242510 NZ_OW706512:1765843-1766061 [Salmonella enterica subsp. enterica serovar Typhi]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14781.69 Da
• Isoelectric Point: 6.4554

>AT242510 WP_031306592.1 NZ_CP095766:c2936928-2936527 [Pseudomonas chengduensis]
MKCPVCGGAELVHDTRDMPFTYKGQTTQITAVTADWCDACGESLTGPAESERVMRAMNEFRQQVNAQDGNQELIRSVRKQ
LRLSQREAAELFGGGPNAFSRYERGSTEAPQPLVQLFKILGRHPELINELRAG

Nucleotide

• Length: 402 bp

>AT242510 NZ_OW706512:1765441-1765815 [Salmonella enterica subsp. enterica serovar Typhi]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A1H2LFQ3