Detailed information of TA system TA242505

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 3321373..3321971
• Replicon: chromosome
• Accession: NZ_CP095765
• Organism: Proteus mirabilis strain T1010

Toxin (Protein)

• Gene name: higB
• Uniprot ID: I1YFL9
• Locus tag: MYO54_RS15475
• Protein ID: WP_001896384.1
• Coordinates: 3321373..3321696 (+)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: MYO54_RS15480
• Protein ID: WP_000058216.1
• Coordinates: 3321693..3321971 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MYO54_RS15445	3317086..3317472	-	387	WP_032469918.1	TraA family conjugative transfer protein	-
MYO54_RS15450	3317469..3318041	-	573	WP_148039504.1	type IV conjugative transfer system lipoprotein TraV	-
MYO54_RS15455	3318116..3319405	-	1290	WP_159262611.1	TraB/VirB10 family protein	-
MYO54_RS15460	3319408..3320304	-	897	WP_159262630.1	type-F conjugative transfer system secretin TraK	-
MYO54_RS15465	3320288..3320914	-	627	WP_159262613.1	TraE/TraK family type IV conjugative transfer system protein	-
MYO54_RS15470	3320911..3321192	-	282	WP_000433891.1	type IV conjugative transfer system protein TraL	-
MYO54_RS15475	3321373..3321696	+	324	WP_001896384.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MYO54_RS15480	3321693..3321971	+	279	WP_000058216.1	helix-turn-helix transcriptional regulator	Antitoxin
MYO54_RS15485	3321997..3322632	-	636	WP_000033756.1	DUF4400 domain-containing protein	-
MYO54_RS15490	3322619..3323179	-	561	WP_159262615.1	conjugative transfer protein	-
MYO54_RS15495	3323189..3325009	-	1821	WP_000661889.1	conjugative transfer system coupling protein TraD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(J) / sul2 / aph(3'')-Ib / aph(6)-Id / aph(3')-VIa	-	3221237..3347821	126584

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (31-81)

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 12281.33 Da
• Isoelectric Point: 9.7658

>T242505 WP_001896384.1 NZ_CP095765:3321373-3321696 [Proteus mirabilis]
MSWKIDFYDGVEDQILDMPPKIQARMIKLLELMEKHGANLGPPHTESMGDGLFEIRAKAQEGIGRGLFCYLKGKHIYVLH
AFVKKSQKTPKNELNLARDRQKEVQKS

Nucleotide

• Length: 324 bp

>T242505 NZ_OW704627:1937458-1937742 [Salmonella enterica subsp. enterica serovar Typhi]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10517.07 Da
• Isoelectric Point: 9.9393

>AT242505 WP_000058216.1 NZ_CP095765:3321693-3321971 [Proteus mirabilis]
MSLQKLKQRALANAEVKNEYDKLESEFSFIDQLLTMRTKAGLTQEQVAERMHTQKSNVSRLEKGNANPSWSTLLKYAHAC
GFELTLKPQKMS

Nucleotide

• Length: 279 bp

>AT242505 NZ_OW704627:1937226-1937468 [Salmonella enterica subsp. enterica serovar Typhi]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCACTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Structures

Toxin

• AlphaFold DB: A0A244CN87