Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 350284..350930 Replicon chromosome
Accession NZ_CP095762
Organism Klebsiella pneumoniae strain KP5362

Toxin (Protein)


Gene name higB Uniprot ID A0A486LFK7
Locus tag MYA94_RS01615 Protein ID WP_023301313.1
Coordinates 350284..350631 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag MYA94_RS01620 Protein ID WP_002920557.1
Coordinates 350631..350930 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYA94_RS01605 (346210) 346210..347643 + 1434 WP_002920564.1 glycogen synthase GlgA -
MYA94_RS01610 (347661) 347661..350108 + 2448 WP_002920561.1 glycogen phosphorylase -
MYA94_RS01615 (350284) 350284..350631 + 348 WP_023301313.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MYA94_RS01620 (350631) 350631..350930 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
MYA94_RS01625 (350993) 350993..352501 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
MYA94_RS01630 (352706) 352706..353035 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
MYA94_RS01635 (353086) 353086..353916 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
MYA94_RS01640 (353966) 353966..354724 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13506.49 Da        Isoelectric Point: 6.2327

>T242478 WP_023301313.1 NZ_CP095762:350284-350631 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKETITMADREFSQHLTKER

Download         Length: 348 bp

>T242478 NZ_OW622535:c3213723-3213427 [Burkholderia mallei]
ATGTTCAAAGTTCTGACGCCCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTATTTCGTGCGGCGCGGAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT242478 WP_002920557.1 NZ_CP095762:350631-350930 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT242478 NZ_OW622535:c3213424-3213068 [Burkholderia mallei]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGAAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTTGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486LFK7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References