Detailed information of TA system TA024246

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1284284..1284887
• Replicon: chromosome
• Accession: NC_013204
• Organism: Eggerthella lenta DSM 2243

Toxin (Protein)

• Gene name: graT
• Uniprot ID: C8WPE4
• Locus tag: ELEN_RS05280
• Protein ID: WP_015760380.1
• Coordinates: 1284284..1284565 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: ELEN_RS05285
• Protein ID: WP_015760381.1
• Coordinates: 1284579..1284887 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ELEN_RS05260	1280564..1281688	+	1125	WP_015760376.1	aldo/keto reductase	-
ELEN_RS05265	1281685..1282317	+	633	WP_015760377.1	7-cyano-7-deazaguanine synthase	-
ELEN_RS05270	1282377..1282871	+	495	WP_049760244.1	GNAT family N-acetyltransferase	-
ELEN_RS05275	1282936..1284252	+	1317	WP_015760379.1	amidohydrolase family protein	-
ELEN_RS05280	1284284..1284565	+	282	WP_015760380.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ELEN_RS05285	1284579..1284887	+	309	WP_015760381.1	HigA family addiction module antidote protein	Antitoxin
ELEN_RS05290	1284889..1286556	-	1668	WP_015760382.1	VWA domain-containing protein	-
ELEN_RS05295	1286578..1287174	-	597	WP_015760383.1	hypothetical protein	-
ELEN_RS05300	1287164..1287739	-	576	WP_015760384.1	sigma-70 family RNA polymerase sigma factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (1-93)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (8-99)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10537.99 Da
• Isoelectric Point: 7.2921

>T24246 WP_015760380.1 NC_013204:1284284-1284565 [Eggerthella lenta DSM 2243]
MIKTFADKDTERLFTDGSCKRISSDVAARTARKLDMIDAALTLEDLRVPPGNRLHALKGDRAGMHAISVNDQWRLCFRFE
GQHAYDVALCDYH

Nucleotide

• Length: 282 bp

>T24246 NC_013204:1284284-1284565 [Eggerthella lenta DSM 2243]
ATGATTAAAACGTTTGCCGATAAAGACACGGAGCGGCTGTTCACCGACGGTTCGTGCAAGCGCATTTCGTCGGACGTGGC
TGCGCGCACGGCGCGCAAGCTCGATATGATCGATGCGGCGCTCACGCTTGAAGACTTGCGGGTTCCGCCCGGTAACAGGC
TGCATGCCCTCAAAGGAGATCGGGCGGGAATGCACGCGATTTCGGTGAACGACCAGTGGCGGCTTTGCTTTCGCTTCGAG
GGCCAGCATGCGTACGATGTCGCGTTGTGCGACTACCATTGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11810.59 Da
• Isoelectric Point: 5.6631

>AT24246 WP_015760381.1 NC_013204:1284579-1284887 [Eggerthella lenta DSM 2243]
MEQHMILMARKPTHPGEVLREEFMPDYGLTVASLAKRLGVSRQSVNEVVRERRAVSTEMAMRLSRLFGTSAEYWLNLQRN
VDLWESLDLHREELDAIEALIA

Nucleotide

• Length: 309 bp

>AT24246 NC_013204:1284579-1284887 [Eggerthella lenta DSM 2243]
ATGGAGCAGCATATGATATTGATGGCGCGCAAGCCCACGCATCCGGGCGAGGTCCTGCGCGAAGAGTTCATGCCCGATTA
CGGGTTGACGGTTGCATCGCTTGCGAAGCGTTTGGGTGTGTCGCGCCAGTCGGTGAACGAAGTGGTGCGCGAGCGGCGCG
CGGTGAGCACCGAGATGGCGATGCGGCTTAGCCGCCTGTTCGGCACGTCGGCCGAGTATTGGCTCAACCTGCAGCGCAAC
GTGGATCTGTGGGAGTCGCTCGACTTGCACCGCGAAGAACTCGACGCCATAGAAGCTTTGATCGCGTAG

Structures

Toxin

• AlphaFold DB: C8WPE4