Detailed information of TA system TA242459

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 2941193..2941919
• Replicon: chromosome
• Accession: NZ_CP095742
• Organism: Luteibacter aegosomatissinici strain 353

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: L2Y97_RS13260
• Protein ID: WP_247427272.1
• Coordinates: 2941614..2941919 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: L2Y97_RS13255
• Protein ID: WP_247427270.1
• Coordinates: 2941193..2941609 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2Y97_RS13235 (L2Y97_13235)	2936238..2937278	+	1041	WP_247427261.1	hypothetical protein	-
L2Y97_RS13240 (L2Y97_13240)	2937281..2938591	+	1311	WP_247427262.1	hypothetical protein	-
L2Y97_RS13245 (L2Y97_13245)	2938948..2939589	+	642	WP_247427265.1	hypothetical protein	-
L2Y97_RS13250 (L2Y97_13250)	2939674..2940909	+	1236	WP_247427267.1	DUF4238 domain-containing protein	-
L2Y97_RS13255 (L2Y97_13255)	2941193..2941609	-	417	WP_247427270.1	transcriptional regulator	Antitoxin
L2Y97_RS13260 (L2Y97_13260)	2941614..2941919	-	306	WP_247427272.1	type II toxin-antitoxin system HigB family toxin	Toxin
L2Y97_RS13265 (L2Y97_13265)	2942087..2942689	+	603	WP_247427275.1	hypothetical protein	-
L2Y97_RS13270 (L2Y97_13270)	2942948..2944582	+	1635	WP_247427277.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	katA	2859061..2987000	127939

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (21-94)

Antitoxin

• Antitoxin HigA (2-137)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11932.75 Da
• Isoelectric Point: 8.8638

>T242459 WP_247427272.1 NZ_CP095742:c2941919-2941614 [Luteibacter aegosomatissinici]
MHVISKRPFTEAATNYPNDADALMRTYRLLDAAEVALPTELKKIFGSLDNFKYEDRWWVIDIGGNNLRLIAFIDFRTGWV
LIKHIVTHADYDRICKKYRER

Nucleotide

• Length: 306 bp

>T242459 NZ_OW443151:c348386-348108 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCCGC
TGAAAAAACGGACGAGGTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATGGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATCGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15303.35 Da
• Isoelectric Point: 4.2538

>AT242459 WP_247427270.1 NZ_CP095742:c2941609-2941193 [Luteibacter aegosomatissinici]
MAFAAIIEKAHSLLDEAPFIGHISNQAEYEQALALVDELFADIEANEVLISVVATAIRRWEDEAEEFSAFNAGLAALDDV
DVLRVLMEQHNLGVADLPEIGGKSLVSRILNRRERNLTKDHIIALSQRFDISPALFFS

Nucleotide

• Length: 417 bp

>AT242459 NZ_OW443151:c348667-348383 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGTCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA