Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3222602..3223183 Replicon chromosome
Accession NZ_CP095741
Organism Luteibacter aegosomaticola strain 335

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag L2Y96_RS14180 Protein ID WP_247327367.1
Coordinates 3222905..3223183 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag L2Y96_RS14175 Protein ID WP_247327357.1
Coordinates 3222602..3222895 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Y96_RS14160 (L2Y96_14160) 3218909..3220432 - 1524 WP_247327337.1 transcription termination factor NusA -
L2Y96_RS14165 (L2Y96_14165) 3220479..3221018 - 540 WP_247327339.1 ribosome maturation factor RimP -
L2Y96_RS14170 (L2Y96_14170) 3221396..3222601 + 1206 WP_247327342.1 GGDEF domain-containing protein -
L2Y96_RS14175 (L2Y96_14175) 3222602..3222895 - 294 WP_247327357.1 HigA family addiction module antitoxin Antitoxin
L2Y96_RS14180 (L2Y96_14180) 3222905..3223183 - 279 WP_247327367.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L2Y96_RS14185 (L2Y96_14185) 3223319..3223738 - 420 WP_247327370.1 hypothetical protein -
L2Y96_RS14190 (L2Y96_14190) 3223785..3224951 - 1167 WP_247327374.1 AAA family ATPase -
L2Y96_RS14195 (L2Y96_14195) 3225029..3226021 - 993 WP_247327377.1 helix-turn-helix domain-containing protein -
L2Y96_RS14200 (L2Y96_14200) 3226021..3226581 - 561 WP_247327380.1 isochorismatase family protein -
L2Y96_RS14205 (L2Y96_14205) 3226703..3227686 - 984 WP_247327383.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-94)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10418.89 Da        Isoelectric Point: 8.3204

>T242455 WP_247327367.1 NZ_CP095741:c3223183-3222905 [Luteibacter aegosomaticola]
MIVSFADKDTEALFHGHCERRWTSIGRVARRKLVQLHAAATLSFLASPPGNRLELLKGGRAGQFSIRINDQFRVCFCWDD
GHAHAVEIVDYH

Download         Length: 279 bp

>T242455 NZ_OW443151:332987-333241 [Vibrio cholerae]
ATGAGAATCGTTTCTTTTACAGAAGCTAGGAATAGTTTAAAAGCAGTCTTGGATGCCGTTGTGAATGATGCGGATACAAC
CGTCATCACTCGACGTGATTCAGAAGATGCCGTGGTTATGTCGCTGGATTATTACAATAGTCTAATGGAAACCGTACATT
TGCTTCGCTCTCCAGCGAACGCTGAACATCTAAACCGTTCCATTGCCCAGTTCAAAGCGGGAAAAGTTACCCAAAGAGAT
CTGATTGATGAGTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10675.28 Da        Isoelectric Point: 8.6769

>AT242455 WP_247327357.1 NZ_CP095741:c3222895-3222602 [Luteibacter aegosomaticola]
MGHPLPPVHPGEVLREDFMKPFGLSSNALALAIGVTAARVNELVSGKRGMTADTALRLARYFGTDPHSWMNLQLHYELEQ
AERRLGDALARIQPRAA

Download         Length: 294 bp

>AT242455 NZ_OW443151:333234-333497 [Vibrio cholerae]
ATGAGTAGTCGTTTACTGTCATGGACAGATGAGTCCTGGGATGACTACTTGTACTGGCAAACACAAGACAAAAAAACACT
CAAGCGGATCAATAAAATCATCAATGATGTTAAGCGTTCACCGTTTGAAGGCATTGGTAAACCAGAGCCTCTAAAAGAAA
ATCTATCTGGTTTTTGGTCTCGACGGATCGATGATACAAATAGACTGGTTTATGCTGTTGATGATAATGCAATAACGATT
ATTTCGTGTCGCTACCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References