Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3908214..3908811 Replicon chromosome
Accession NZ_CP095557
Organism Klebsiella pneumoniae strain BA11088

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag MXX37_RS19215 Protein ID WP_004142563.1
Coordinates 3908494..3908811 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag MXX37_RS19210 Protein ID WP_004142561.1
Coordinates 3908214..3908501 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MXX37_RS19180 (3904309) 3904309..3904557 + 249 WP_002893037.1 DUF1158 domain-containing protein -
MXX37_RS19185 (3904575) 3904575..3904916 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
MXX37_RS19190 (3904947) 3904947..3906062 - 1116 WP_012737592.1 MBL fold metallo-hydrolase -
MXX37_RS19195 (3906242) 3906242..3906826 + 585 WP_071579668.1 TetR/AcrR family transcriptional regulator -
MXX37_RS19200 (3906823) 3906823..3907191 + 369 WP_040171587.1 MmcQ/YjbR family DNA-binding protein -
MXX37_RS19205 (3907311) 3907311..3907949 + 639 WP_064277739.1 oxygen-insensitive NAD(P)H nitroreductase -
MXX37_RS19210 (3908214) 3908214..3908501 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
MXX37_RS19215 (3908494) 3908494..3908811 - 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MXX37_RS19220 (3908996) 3908996..3910039 - 1044 WP_040153598.1 DUF2157 domain-containing protein -
MXX37_RS19225 (3910709) 3910709..3911575 - 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
MXX37_RS19230 (3911684) 3911684..3913111 + 1428 WP_009308097.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T242420 WP_004142563.1 NZ_CP095557:c3908811-3908494 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

>T242420 NZ_OW052571:3716268-3716681 [Mycobacterium tuberculosis]
GTGAGAGCATCGCCCACTTCGCCGCCGGAGCAGGTGGTCGTCGACGCGAGTGCCATGGTGGATCTACTGGCTCGCACTAG
CGATCGGTGCTCTGCGGTGCGCGCGCGGCTGGCTCGGACCGCGATGCACGCGCCGGCGCACTTCGATGCAGAGGTGTTGT
CGGCGCTGGGGCGCATGCAGCGCGCCGGCGCACTCACCGTTGCCTATGTCGATGCGGCACTGGAGGAGTTGCGACAGGTG
CCGGTGACTCGACACGGTCTTTCGTCGCTGCTTGCTGGAGCGTGGTCGCGCCGCGACACCCTCCGCCTGACCGATGCCCT
CTACGTCGAGCTGGCCGAAACGGCAGGTCTGGTGTTGTTGACCACCGACGAAAGATTGGCACGCGCCTGGCCCTCGGCTC
ACGCCATCGGCTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT242420 WP_004142561.1 NZ_CP095557:c3908501-3908214 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp

>AT242420 NZ_OW052571:3716005-3716271 [Mycobacterium tuberculosis]
TTGTTGAGCCGGCGCACGAAAACGATCGTTGTGTGTACATTGGTGTGTATGGCTCGGTTGAACGTGTATGTGCCCGACGA
ATTGGCGGAGCGCGCCAGGGCGCGGGGCTTGAACGTCTCGGCGCTGACTCAGGCCGCGATCAGTGCCGAGTTGGAGAACT
CCGCAACCGATGCGTGGCTTGAGGGGTTGGAACCCAGAAGCACCGGCGCTCGGCATGATGACGTGCTGGGTGCGATCGAT
GCCGCTCGCGATGAGTTCGAAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References