242384

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 1183391..1184709 Replicon chromosome
Accession NZ_CP095540
Organism Escherichia coli strain GN03204

Toxin (Protein)


Gene name HipT Uniprot ID F4T5A3
Locus tag MW399_RS05575 Protein ID WP_001262467.1
Coordinates 1183702..1184709 (+) Length 336 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID F4T5A4
Locus tag MW399_RS05570 Protein ID WP_001312177.1
Coordinates 1183391..1183702 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MW399_RS05545 (1178923) 1178923..1179942 + 1020 WP_000938855.1 dipeptide ABC transporter permease DppB -
MW399_RS05550 (1179952) 1179952..1180854 + 903 WP_000084677.1 dipeptide ABC transporter permease DppC -
MW399_RS05555 (1180865) 1180865..1181848 + 984 WP_001196477.1 dipeptide ABC transporter ATP-binding protein -
MW399_RS05560 (1181845) 1181845..1182858 + 1014 WP_000103572.1 dipeptide ABC transporter ATP-binding subunit DppF -
MW399_RS05565 (1183083) 1183083..1183406 + 324 WP_000563102.1 helix-turn-helix transcriptional regulator -
MW399_RS05570 (1183391) 1183391..1183702 + 312 WP_001312177.1 HipA N-terminal domain-containing protein Antitoxin
MW399_RS05575 (1183702) 1183702..1184709 + 1008 WP_001262467.1 HipA domain-containing protein Toxin
MW399_RS05580 (1184726) 1184726..1185997 - 1272 WP_001545666.1 amino acid permease -
- (1186359) 1186359..1186424 - 66 NuclAT_27 - -
- (1186359) 1186359..1186424 - 66 NuclAT_27 - -
- (1186359) 1186359..1186424 - 66 NuclAT_27 - -
- (1186359) 1186359..1186424 - 66 NuclAT_27 - -
MW399_RS05585 (1186473) 1186473..1186580 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
- (1186842) 1186842..1186899 - 58 NuclAT_26 - -
- (1186842) 1186842..1186899 - 58 NuclAT_26 - -
- (1186842) 1186842..1186899 - 58 NuclAT_26 - -
- (1186842) 1186842..1186899 - 58 NuclAT_26 - -
MW399_RS05590 (1186956) 1186956..1187063 + 108 WP_000170748.1 type I toxin-antitoxin system toxin Ldr family protein -
MW399_RS05595 (1187439) 1187439..1187546 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
MW399_RS05600 (1187632) 1187632..1189311 - 1680 Protein_1082 cellulose biosynthesis protein BcsG -
MW399_RS05605 (1189308) 1189308..1189499 - 192 WP_000988308.1 cellulose biosynthesis protein BcsF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-302)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 336 a.a.        Molecular weight: 38320.60 Da        Isoelectric Point: 5.5965

>T242384 WP_001262467.1 NZ_CP095540:1183702-1184709 [Escherichia coli]
MANCRILLTPLNERDEQRGYSTQGLKRLSGTAKLTPRLGFTRTQFVQELPRQQKGMSISGYQPKLQLVLDEGEFRVVDHQ
GNFILKPSPADFPGLAENEHATMTLMSRLGFDVPVHGLLSFAPQSEEELEYAFVIRRYDRDNKGLPVHQEQLDGAMQIMD
KYGKTGNDNEQYVSYETLARFLVAHVNDNIAFKIDLFRRIVYAWLLGNNDMHLRNFGLVYSDGLTPALAPVYDFVSVAPY
PEYFHSNYLALPLLTREEGGRELAPGFHSDYGEYIGQDFLLLGESMGLAPRLLEKLFQDIRKENAIVMETYEQSFMTQDH
IQAVLQCYRHRLGLL

Download         Length: 1008 bp

>T242384 NZ_OW052571:1510528-1510947 [Mycobacterium tuberculosis]
GTGACGGCACTGCTCGATGTCAATGTGCTGATCGCGCTGGGCTGGCCGAATCACGTTCACCATGCGGCCGCGCAGCGATG
GTTCACGCAGTTCTCCTCGAATGGGTGGGCCACCACGCCGATCACCGAGGCAGGGTATGTCCGAATTTCAAGCAATCGCA
GTGTGATGCAGGTGTCGACCACGCCGGCTATCGCGATCGCTCAGTTGGCGGCGATGACTTCTCTTGCCGGGCACACGTTT
TGGCCTGACGATGTGCCACTGATCGTTGGGAGCGCCGGCGATCGCGATGCGGTGTCCAACCACCGTCGGGTCACCGACTG
CCATCTCATCGCCTTGGCCGCGCGCTACGGGGGCCGGTTGGTCACATTCGATGCCGCACTGGCCGATTCAGCATCCGCAG
GCCTCGTCGAGGTGTTGTAG

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11821.47 Da        Isoelectric Point: 6.0609

>AT242384 WP_001312177.1 NZ_CP095540:1183391-1183702 [Escherichia coli]
MHRRVKVLLYGQVVGELSQNDSGFLFQYAPDYHGPAISISLPVAQRQFPSEMLHPYFASLAPEGWLRQRYSQIQHRDEND
LLGMLIDNGKNLLGAIQILPWEE

Download         Length: 312 bp

>AT242384 NZ_OW052571:1510307-1510531 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGCAGATTGATGATGATGTTCTAGAAGATGCTCGTAGCATCGCGCGGTCGGAGGGCAAGTCAGTCGG
CGCGGTAATTTCTGAGTTGGCGCGTAGGTCGCTCCGTCCGGTTGGGATTGTCGAGGTTGACGGATTTCCGGTTTTTGATG
TTCCGCCGGATGCGCCGACGGTGACTTCCGAGGATGTCGTCCGCGCGCTCGAGGACGACGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3K2ZTB5

Antitoxin

Source ID Structure
AlphaFold DB A0A3L3HKE2

References