Detailed information of TA system TA242370

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4006692..4006950
• Replicon: chromosome
• Accession: NZ_CP095538
• Organism: Escherichia coli strain GN04592

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: MW396_RS19705
• Protein ID: WP_000809168.1
• Coordinates: 4006798..4006950 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4006692..4006749 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MW396_RS19690	4003084..4004043	+	960	WP_000871674.1	hypothetical protein	-
MW396_RS19695	4004081..4004980	-	900	WP_001300855.1	transcriptional activator NhaR	-
MW396_RS19700	4005046..4006212	-	1167	WP_000681360.1	Na+/H+ antiporter NhaA	-
-	4006692..4006749	-	58	-	-	Antitoxin
MW396_RS19705	4006798..4006950	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
MW396_RS19710	4007054..4008184	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
MW396_RS19715	4008273..4010189	-	1917	WP_000516135.1	molecular chaperone DnaK	-
MW396_RS19720	4010565..4010969	+	405	WP_000843584.1	DUF2541 family protein	-
MW396_RS19725	4010995..4011708	+	714	WP_001102367.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T242370 WP_000809168.1 NZ_CP095538:4006798-4006950 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T242370 NZ_OW052571:662008-662436 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT242370 NZ_CP095538:c4006749-4006692 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin