Detailed information of TA system TA024237

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 1798338..1798871
• Replicon: chromosome
• Accession: NC_013174
• Organism: Jonesia denitrificans DSM 20603

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: C7QYS0
• Locus tag: JDEN_RS08365
• Protein ID: WP_015771937.1
• Coordinates: 1798338..1798592 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: C7QYS1
• Locus tag: JDEN_RS08370
• Protein ID: WP_015771938.1
• Coordinates: 1798593..1798871 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JDEN_RS08345	1793397..1795178	+	1782	WP_015771933.1	thiol reductant ABC exporter subunit CydC	-
JDEN_RS08350	1795244..1796449	+	1206	WP_105597338.1	GAF domain-containing protein	-
JDEN_RS08355	1796459..1797082	-	624	WP_015771935.1	response regulator transcription factor	-
JDEN_RS08360	1797228..1798196	+	969	WP_015771936.1	D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding subunit	-
JDEN_RS08365	1798338..1798592	-	255	WP_015771937.1	Txe/YoeB family addiction module toxin	Toxin
JDEN_RS08370	1798593..1798871	-	279	WP_015771938.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
JDEN_RS13455	1798825..1799199	+	375	WP_083775133.1	hypothetical protein	-
JDEN_RS08375	1799135..1799686	+	552	WP_015771939.1	GNAT family N-acetyltransferase	-
JDEN_RS08380	1799697..1800626	-	930	WP_015771940.1	bifunctional DNA-formamidopyrimidine glycosylase/DNA-(apurinic or apyrimidinic site) lyase	-
JDEN_RS08385	1800633..1801373	-	741	WP_049754459.1	ribonuclease III	-
JDEN_RS08390	1801396..1801590	-	195	WP_015771942.1	50S ribosomal protein L32	-
JDEN_RS08395	1801593..1802084	-	492	WP_083775215.1	DUF177 domain-containing protein	-
JDEN_RS08400	1802291..1802794	-	504	WP_105597337.1	hypothetical protein	-
JDEN_RS08405	1802873..1803355	-	483	WP_015771946.1	pantetheine-phosphate adenylyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-70)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10110.50 Da
• Isoelectric Point: 6.7175

>T24237 WP_015771937.1 NC_013174:c1798592-1798338 [Jonesia denitrificans DSM 20603]
VRLVWDEAAWEDYKHWQTADRRVLKRINLLIDACLREPFEGIGKPEQLKYGVQGSWSRRINEEHRLVYLVDGDDLVILQA
RYHY

Nucleotide

• Length: 255 bp

>T24237 NC_013174:c1798592-1798338 [Jonesia denitrificans DSM 20603]
GTGCGGCTGGTTTGGGACGAGGCCGCCTGGGAGGACTACAAGCACTGGCAGACGGCCGACCGGAGGGTCCTCAAGCGGAT
CAACCTGCTCATTGACGCCTGCCTGCGCGAGCCGTTCGAGGGCATTGGCAAGCCTGAGCAGCTGAAGTACGGCGTGCAGG
GCTCGTGGTCCCGGCGGATCAATGAGGAGCACAGGCTCGTCTATCTCGTCGACGGCGACGATCTCGTGATCCTGCAGGCC
CGCTACCACTACTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10366.60 Da
• Isoelectric Point: 5.7185

>AT24237 WP_015771938.1 NC_013174:c1798871-1798593 [Jonesia denitrificans DSM 20603]
MSISASEARKTLFPLIERVNQDHEAIEIVSRKGNAVLMPADEYAAWQETAYLFRSPANARRLLDAYDRARAGKVQAHELD
RSDEPADQPRGI

Nucleotide

• Length: 279 bp

>AT24237 NC_013174:c1798871-1798593 [Jonesia denitrificans DSM 20603]
ATGTCCATCAGCGCGAGCGAGGCCCGCAAGACGCTGTTTCCGCTCATCGAGCGCGTGAACCAGGATCACGAAGCTATCGA
GATCGTCTCCCGCAAGGGCAACGCGGTGCTCATGCCGGCCGACGAGTACGCCGCCTGGCAGGAGACCGCCTACCTGTTCC
GCTCGCCGGCGAACGCGCGCAGGCTGCTCGACGCCTACGACCGCGCCCGCGCCGGGAAGGTGCAGGCTCACGAACTCGAC
CGCTCCGACGAGCCCGCAGATCAGCCTCGGGGCATCTGA

Structures

Toxin

• AlphaFold DB: C7QYS0

Antitoxin

• AlphaFold DB: C7QYS1