Detailed information of TA system TA242298

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 2240653..2241024
• Replicon: chromosome
• Accession: NZ_CP095529
• Organism: Escherichia coli strain GN06156

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: A0A1Y2ZGM7
• Locus tag: MW397_RS10670
• Protein ID: WP_042038331.1
• Coordinates: 2240830..2241024 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	2240653..2240831 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MW397_RS10645 (2236608)	2236608..2237981	+	1374	WP_000123708.1	ATP-dependent RNA helicase DbpA	-
MW397_RS10650 (2238110)	2238110..2239045	-	936	WP_001157407.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
MW397_RS10655 (2239097)	2239097..2240332	-	1236	WP_072037536.1	site-specific integrase	-
MW397_RS10660 (2240334)	2240334..2240549	-	216	WP_000079604.1	excisionase XisR	-
- (2240653)	2240653..2240831	+	179	NuclAT_0	-	Antitoxin
- (2240653)	2240653..2240831	+	179	NuclAT_0	-	Antitoxin
- (2240653)	2240653..2240831	+	179	NuclAT_0	-	Antitoxin
- (2240653)	2240653..2240831	+	179	NuclAT_0	-	Antitoxin
MW397_RS10665 (2240649)	2240649..2240837	-	189	WP_001302840.1	DUF1187 family protein	-
MW397_RS10670 (2240830)	2240830..2241024	-	195	WP_042038331.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
MW397_RS10675 (2241081)	2241081..2241890	-	810	WP_000166319.1	recombination protein RecT	-
MW397_RS10680 (2241883)	2241883..2244483	-	2601	WP_000105133.1	exodeoxyribonuclease VIII	-
MW397_RS10685 (2244585)	2244585..2244860	-	276	WP_000632297.1	protein RacC	-
MW397_RS10690 (2244935)	2244935..2245105	-	171	WP_001485242.1	YdaE family protein	-
MW397_RS10695 (2245105)	2245105..2245326	-	222	WP_000560223.1	killing protein KilR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2239097..2287555	48458

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7046.94 Da
• Isoelectric Point: 8.9538

>T242298 WP_042038331.1 NZ_CP095529:c2241024-2240830 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKVISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Nucleotide

• Length: 195 bp

>T242298 NZ_OW052302:3680746-3681162 [Mycobacterium tuberculosis]
ATGACCACGCGCTATTTGCTCGACAAATCAGCGGCTTACCGCGCGCACTTGCCCGCGGTCCGACATCGCTTGGAACCGTT
GATGGAACGCGGTCTACTGGCCCGGTGCGGCATTACCGATCTCGAGTTCGGAGTCTCGGCGCGTTCCCGCGAGGACCATC
GAACACTGGGCACCTACCGGCGTGACGCGCTCGAATACGTCAACACCCCCGACACCGTGTGGGTTCGTGCATGGGAGATC
CAAGAAGCATTGACCGACAAGGGATTTCACCGCTCGGTCAAGATCCCGGACTTGATCATTGCGGCGGTCGCCGAGCATCA
CGGCATACCCGTCATGCACTACGACCAAGACTTCGAACGCATCGCCGCCATCACACGGCAACCCGTGGAATGGGTGGTGG
CCCCAGGGACAGCGTGA

Antitoxin

Nucleotide

• Length: 179 bp

>AT242298 NZ_CP095529:2240653-2240831 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A1Y2ZGM7

Antitoxin