Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1080486..1081136 Replicon chromosome
Accession NZ_CP095529
Organism Escherichia coli strain GN06156

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MW397_RS05030 Protein ID WP_000263532.1
Coordinates 1080486..1080827 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID D3GSB3
Locus tag MW397_RS05035 Protein ID WP_000212551.1
Coordinates 1080837..1081136 (+) Length 100 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MW397_RS05005 (1075521) 1075521..1076621 + 1101 WP_001181876.1 flagellar basal body P-ring protein FlgI -
MW397_RS05010 (1076621) 1076621..1076920 + 300 WP_000867281.1 rod-binding protein -
MW397_RS05015 (1077096) 1077096..1078472 + 1377 WP_000367245.1 flagellar hook-associated protein FlgK -
MW397_RS05020 (1078487) 1078487..1079416 + 930 WP_001266799.1 flagellar hook-associated protein FlgL -
MW397_RS05025 (1079433) 1079433..1080410 + 978 WP_001195938.1 hypothetical protein -
MW397_RS05030 (1080486) 1080486..1080827 + 342 WP_000263532.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MW397_RS05035 (1080837) 1080837..1081136 + 300 WP_000212551.1 XRE family transcriptional regulator Antitoxin
MW397_RS05040 (1081194) 1081194..1082036 - 843 WP_000022366.1 winged helix-turn-helix domain-containing protein -
MW397_RS05045 (1082522) 1082522..1083436 + 915 WP_000949083.1 lateral flagellin LafA -
MW397_RS05050 (1083641) 1083641..1084957 + 1317 WP_000609678.1 flagellar filament capping protein FliD -
MW397_RS05055 (1084980) 1084980..1085372 + 393 WP_000285322.1 flagellar export chaperone FliS -
MW397_RS05060 (1085377) 1085377..1085688 + 312 WP_000415004.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-107)

Antitoxin

(8-88)


Sequences


Toxin        


Download         Length: 114 a.a.        Molecular weight: 13031.86 Da        Isoelectric Point: 6.4677

>T242290 WP_000263532.1 NZ_CP095529:1080486-1080827 [Escherichia coli]
MWDVETTETFDNWFDAQTVALKEDLLAAMLILAEYGPQLGRPFADTVNDSQFSNMKELRVQHQGNPVRAFFAFDPARRGI
VLCAGDKTGLNEKKFYRDMIKLADSEYRKHLKK

Download         Length: 342 bp

>T242290 NZ_OW052302:3044480-3044908 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10976.81 Da        Isoelectric Point: 9.7665

>AT242290 WP_000212551.1 NZ_CP095529:1080837-1081136 [Escherichia coli]
MATLKELMAKQSPESQARIAAKVEEMRQTIALHQLREELNISQTEMAAAMGIKQPTLAKMEQADNDPRLSTLKRYVAALG
GELSIDVKLPNGKRIAFQI

Download         Length: 300 bp

>AT242290 NZ_OW052302:3044234-3044476 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB D3GSB3

References