Detailed information of TA system TA242288

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 782572..782830
• Replicon: chromosome
• Accession: NZ_CP095529
• Organism: Escherichia coli strain GN06156

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: MW397_RS03660
• Protein ID: WP_000809168.1
• Coordinates: 782572..782724 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	782773..782830 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MW397_RS03640	777814..778527	-	714	WP_024229863.1	acidic protein MsyB	-
MW397_RS03645	778553..778957	-	405	WP_029305728.1	DUF2541 family protein	-
MW397_RS03650	779333..781249	+	1917	WP_000516135.1	molecular chaperone DnaK	-
MW397_RS03655	781338..782468	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
MW397_RS03660	782572..782724	-	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
-	782773..782830	+	58	-	-	Antitoxin
MW397_RS03665	783310..784476	+	1167	WP_000681360.1	Na+/H+ antiporter NhaA	-
MW397_RS03670	784542..785441	+	900	WP_001300855.1	transcriptional activator NhaR	-
MW397_RS03675	785479..786438	-	960	WP_000871674.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T242288 WP_000809168.1 NZ_CP095529:c782724-782572 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T242288 NZ_OW052302:2948457-2948849 [Mycobacterium tuberculosis]
ATGGCGGCCATCTATCTCGACTCGTCCGCGATCGTCAAGCTCGCGGTTCGCGAGCCAGAGTCGGACGCGCTGCGCCGCTA
CCTTCGCACCCGCCACCCGCGAGTGTCGAGTGCCCTTGCGCGCACGGAGGTCATGCGGGCCCTGCTTGACAAGGGTGAAT
CAGCGCGGAAAGCCGGCCGCCGGGCGCTGGCTCATCTCGATCTGCTGCGCGTCGACAAGCGCGTCCTCGATCTCGCTGGT
GGGCTGCTGCCATTCGAGCTGCGCACGCTCGATGCCATCCACTTGGCGACGGCGCAGCGGCTCGGCGTCGATCTGGGCCG
GTTGTGCACCTACGACGACCGGATGCGCGACGCCGCCAAGACGCTCGGCATGGCCGTGATCGCCCCGTCGTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT242288 NZ_CP095529:782773-782830 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin