Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 139529..140045 Replicon chromosome
Accession NC_013169
Organism Kytococcus sedentarius DSM 20547

Toxin (Protein)


Gene name yoeB Uniprot ID C7NJ00
Locus tag KSED_RS00650 Protein ID WP_012801644.1
Coordinates 139529..139786 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C7NJ01
Locus tag KSED_RS00655 Protein ID WP_012801645.1
Coordinates 139788..140045 (-) Length 86 a.a.

Genomic Context

KSED_RS00625KSED_RS13960KSED_RS13965KSED_RS00645KSED_RS13250KSED_RS13255KSED_RS00670KSED_RS00675KSED_RS00640KSED_RS00650KSED_RS00655KSED_RS00680KSED_RS00685
Location: 134726..136471 (1746 bp)
Type: Others
Protein ID: WP_012801639.1
Location: 136514..136828 (315 bp)
Type: Others
Protein ID: WP_012801640.1
Location: 136884..137861 (978 bp)
Type: Others
Protein ID: WP_143827315.1
Location: 139102..139515 (414 bp)
Type: Others
Protein ID: WP_041291019.1
Location: 140155..140691 (537 bp)
Type: Others
Protein ID: WP_012801646.1
Location: 140695..141084 (390 bp)
Type: Others
Protein ID: WP_012801647.1
Location: 141262..142398 (1137 bp)
Type: Others
Protein ID: WP_012801648.1
Location: 142462..142959 (498 bp)
Type: Others
Protein ID: WP_041290814.1
Location: 138090..139055 (966 bp)
Type: Others
Protein ID: WP_012801642.1
Location: 139529..139786 (258 bp)
Type: Toxin
Protein ID: WP_012801644.1
Location: 139788..140045 (258 bp)
Type: Antitoxin
Protein ID: WP_012801645.1
Location: 142997..143974 (978 bp)
Type: Others
Protein ID: WP_012801650.1
Location: 143979..144680 (702 bp)
Type: Others
Protein ID: WP_012801651.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KSED_RS00625134726..136471+1746WP_012801639.1ABC transporter ATP-binding protein/permease-
KSED_RS13960136514..136828+315WP_012801640.1MerR family transcriptional regulator-
KSED_RS13965136884..137861+978WP_143827315.1GNAT family N-acetyltransferase-
KSED_RS00640138090..139055-966WP_012801642.1winged helix-turn-helix domain-containing protein-
KSED_RS00645139102..139515+414WP_041291019.1glyoxalase-
KSED_RS00650139529..139786-258WP_012801644.1Txe/YoeB family addiction module toxinToxin
KSED_RS00655139788..140045-258WP_012801645.1type II toxin-antitoxin system prevent-host-death family antitoxinAntitoxin
KSED_RS13250140155..140691+537WP_012801646.1GNAT family N-acetyltransferase-
KSED_RS13255140695..141084+390WP_012801647.1VOC family protein-
KSED_RS00670141262..142398+1137WP_012801648.1FAD-dependent oxidoreductase-
KSED_RS00675142462..142959+498WP_041290814.1tetratricopeptide repeat protein-
KSED_RS00680142997..143974-978WP_012801650.1DUF2332 domain-containing protein-
KSED_RS00685143979..144680-702WP_012801651.1class I SAM-dependent methyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--127476..14295915483


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10146.45 Da        Isoelectric Point: 8.9192

>T24226 WP_012801644.1 NC_013169:c139786-139529 [Kytococcus sedentarius DSM 20547]
VRLVWDENAWEDYLWWQAQDRKVLKRINTLLKDVARNGNEGTGKPEALKHSLAGYWSRRITDEHRLVHKVTEDEIRIAAC
RYHYG

Download         Length: 258 bp

>T24226 NC_013169:c139786-139529 [Kytococcus sedentarius DSM 20547]
GTGCGCCTGGTCTGGGACGAGAACGCCTGGGAGGACTACCTCTGGTGGCAGGCCCAGGACCGCAAGGTGCTCAAGCGGAT
CAACACCCTGCTCAAGGACGTCGCCCGGAACGGCAACGAGGGCACCGGCAAGCCCGAGGCCCTGAAGCACAGCCTCGCCG
GGTACTGGTCCCGCCGCATCACCGACGAGCACCGCCTCGTCCACAAGGTCACCGAGGACGAGATCCGCATCGCAGCCTGC
CGGTACCACTACGGGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9729.83 Da        Isoelectric Point: 4.4985

>AT24226 WP_012801645.1 NC_013169:c140045-139788 [Kytococcus sedentarius DSM 20547]
VKTLSYTESRRRYAEVLDHVVDDREEVVITRAGHEPVVIVSLEEYESLRETAYLMRSPANARRLLDAMDRLEAGGGTEHE
LIETD

Download         Length: 258 bp

>AT24226 NC_013169:c140045-139788 [Kytococcus sedentarius DSM 20547]
GTGAAGACGCTCAGCTACACCGAGTCACGCCGGCGATACGCCGAGGTGCTCGACCACGTGGTGGACGACCGCGAGGAGGT
CGTCATCACCCGCGCCGGGCACGAGCCCGTCGTCATCGTGTCCCTGGAGGAGTACGAGTCCCTCCGCGAGACCGCCTACC
TCATGCGGTCCCCGGCCAACGCCCGCCGCCTGCTCGACGCCATGGACCGCCTCGAGGCCGGCGGCGGCACCGAGCACGAG
CTGATCGAGACCGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBC7NJ00

Antitoxin

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Source
ID
Structure
AlphaFold DBC7NJ01

References