Detailed information of TA system TA242173

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 1295909..1296321
• Replicon: chromosome
• Accession: NZ_CP095518
• Organism: Escherichia coli strain GN02350

Toxin (Protein)

• Gene name: symE
• Uniprot ID: U9YSY7
• Locus tag: MW405_RS06130
• Protein ID: WP_000132601.1
• Coordinates: 1295980..1296321 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	1295909..1295985 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MW405_RS06120 (1292772)	1292772..1294361	+	1590	WP_001063204.1	type I restriction-modification system methyltransferase	-
MW405_RS06125 (1294358)	1294358..1295752	+	1395	WP_001272447.1	type I restriction-modification system specificity subunit	-
- (1295909)	1295909..1295985	-	77	NuclAT_5	-	Antitoxin
- (1295909)	1295909..1295985	-	77	NuclAT_5	-	Antitoxin
- (1295909)	1295909..1295985	-	77	NuclAT_5	-	Antitoxin
- (1295909)	1295909..1295985	-	77	NuclAT_5	-	Antitoxin
- (1295909)	1295909..1295985	-	77	NuclAT_6	-	Antitoxin
- (1295909)	1295909..1295985	-	77	NuclAT_6	-	Antitoxin
- (1295909)	1295909..1295985	-	77	NuclAT_6	-	Antitoxin
- (1295909)	1295909..1295985	-	77	NuclAT_6	-	Antitoxin
MW405_RS06130 (1295980)	1295980..1296321	+	342	WP_000132601.1	endoribonuclease SymE	Toxin
MW405_RS06135 (1296483)	1296483..1297862	+	1380	WP_000443951.1	5-methylcytosine-specific restriction endonuclease subunit McrB	-
MW405_RS06140 (1297862)	1297862..1298908	+	1047	WP_000437621.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12203.02 Da
• Isoelectric Point: 8.5012

>T242173 WP_000132601.1 NZ_CP095518:1295980-1296321 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T242173 NZ_OW052188:c3014503-3014126 [Mycobacterium tuberculosis]
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT242173 NZ_CP095518:c1295985-1295909 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCAGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: U9YSY7

Antitoxin