Detailed information of TA system TA242171

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1214136..1214394
• Replicon: chromosome
• Accession: NZ_CP095518
• Organism: Escherichia coli strain GN02350

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: MW405_RS05740
• Protein ID: WP_000809168.1
• Coordinates: 1214242..1214394 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	1214136..1214193 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MW405_RS05725	1209965..1211224	-	1260	WP_000494928.1	hypothetical protein	-
MW405_RS05730	1211353..1212846	-	1494	WP_001468392.1	sulfatase-like hydrolase/transferase	-
MW405_RS05735	1212866..1213627	-	762	WP_020231698.1	outer membrane protein OmpK	-
-	1214136..1214193	-	58	-	-	Antitoxin
MW405_RS05740	1214242..1214394	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
MW405_RS05745	1214499..1215629	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
MW405_RS05750	1215718..1217634	-	1917	WP_000516135.1	molecular chaperone DnaK	-
MW405_RS05755	1218007..1218411	+	405	WP_000843687.1	DUF2541 family protein	-
MW405_RS05760	1218437..1219150	+	714	WP_001102393.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T242171 WP_000809168.1 NZ_CP095518:1214242-1214394 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T242171 NZ_OW052188:c2953010-2952570 [Mycobacterium tuberculosis]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT242171 NZ_CP095518:c1214193-1214136 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin