Detailed information of TA system TA024217

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1338853..1339464
• Replicon: chromosome
• Accession: NC_013037
• Organism: Dyadobacter fermentans DSM 18053

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C6W513
• Locus tag: DFER_RS05545
• Protein ID: WP_015810627.1
• Coordinates: 1339186..1339464 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: DFER_RS05540
• Protein ID: WP_041735960.1
• Coordinates: 1338853..1339173 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DFER_RS05525	1334623..1337058	+	2436	WP_015810623.1	ABC transporter permease	-
DFER_RS05530	1337173..1338291	+	1119	WP_015810624.1	hypothetical protein	-
DFER_RS05535	1338345..1338827	+	483	WP_015810625.1	PA2169 family four-helix-bundle protein	-
DFER_RS05540	1338853..1339173	-	321	WP_041735960.1	HigA family addiction module antidote protein	Antitoxin
DFER_RS05545	1339186..1339464	-	279	WP_015810627.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DFER_RS05550	1339619..1340143	+	525	WP_041735963.1	RNA polymerase sigma factor	-
DFER_RS05555	1340130..1340984	+	855	WP_015810629.1	HEAT repeat domain-containing protein	-
DFER_RS05560	1341005..1341871	+	867	WP_015810630.1	hypothetical protein	-
DFER_RS05565	1341876..1342706	+	831	WP_015810631.1	DUF4097 family beta strand repeat protein	-
DFER_RS05570	1342799..1343188	-	390	WP_143828675.1	MarR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-74)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10545.00 Da
• Isoelectric Point: 9.8637

>T24217 WP_015810627.1 NC_013037:c1339464-1339186 [Dyadobacter fermentans DSM 18053]
VIVTYRHKGLELYARKGDRSKLPQAHLARVRLILTRLDAAANAIEMNQPGYHFHALTGDLKGYHSVRVSGNYRIIFRFEG
GNAFDVDYVDYH

Nucleotide

• Length: 279 bp

>T24217 NC_013037:c1339464-1339186 [Dyadobacter fermentans DSM 18053]
GTGATTGTAACTTACCGGCATAAAGGGCTGGAACTATACGCACGCAAAGGAGACCGTTCAAAGTTGCCGCAAGCGCATCT
GGCACGGGTCCGGCTTATTTTAACGCGACTGGATGCGGCGGCAAATGCCATCGAAATGAACCAGCCGGGTTACCATTTCC
ATGCTTTGACCGGCGACTTAAAGGGTTACCATTCCGTGAGAGTGTCCGGCAATTACCGGATCATTTTCAGGTTTGAAGGA
GGAAATGCATTTGATGTAGACTATGTGGATTACCACTAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11638.24 Da
• Isoelectric Point: 5.1316

>AT24217 WP_041735960.1 NC_013037:c1339173-1338853 [Dyadobacter fermentans DSM 18053]
MAIFDPAHPGELIRETIEGLREETGQRLTIAEVAEGLGVTRKTLSAILNAKQGVTPEMAIRLATAFANTTPEFWLNAQEN
YDLAKARQTVDVSKIRVFWQPNAASA

Nucleotide

• Length: 321 bp

>AT24217 NC_013037:c1339173-1338853 [Dyadobacter fermentans DSM 18053]
ATGGCAATTTTTGATCCCGCACACCCAGGAGAACTGATCAGGGAAACGATAGAGGGACTAAGGGAAGAAACAGGTCAGCG
ACTGACGATCGCAGAGGTGGCCGAAGGGCTGGGAGTAACCCGAAAGACCTTATCGGCGATTCTCAATGCGAAACAGGGCG
TAACGCCGGAAATGGCAATCCGCCTCGCCACGGCATTCGCCAACACGACACCGGAATTTTGGCTGAATGCCCAGGAGAAC
TACGATCTCGCAAAGGCCAGGCAGACGGTAGATGTGAGCAAGATCCGTGTGTTCTGGCAACCGAATGCCGCGTCGGCATA
A

Structures

Toxin

• AlphaFold DB: C6W513