Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4561478..4561736 Replicon chromosome
Accession NZ_CP095510
Organism Escherichia coli strain GN02270

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag MW401_RS22090 Protein ID WP_000809168.1
Coordinates 4561584..4561736 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4561478..4561535 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MW401_RS22075 4557870..4558829 + 960 WP_000871674.1 hypothetical protein -
MW401_RS22080 4558867..4559766 - 900 WP_001300855.1 transcriptional activator NhaR -
MW401_RS22085 4559832..4560998 - 1167 WP_000681360.1 Na+/H+ antiporter NhaA -
- 4561478..4561535 - 58 - - Antitoxin
MW401_RS22090 4561584..4561736 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
MW401_RS22095 4561840..4562970 - 1131 WP_001118464.1 molecular chaperone DnaJ -
MW401_RS22100 4563059..4564975 - 1917 WP_000516135.1 molecular chaperone DnaK -
MW401_RS22105 4565351..4565755 + 405 WP_000843584.1 DUF2541 family protein -
MW401_RS22110 4565781..4566494 + 714 WP_001102367.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T242121 WP_000809168.1 NZ_CP095510:4561584-4561736 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T242121 NZ_OV904788:998657-998836 [Streptococcus pneumoniae]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAGAAGCAAGGGGAAAGACTTATCACAATCCCTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 58 bp

>AT242121 NZ_CP095510:c4561535-4561478 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References