Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2028041..2028741 Replicon chromosome
Accession NZ_CP095497
Organism Burkholderia cepacia strain BRDJ

Toxin (Protein)


Gene name mqsR Uniprot ID A0A4S5DDW5
Locus tag MW307_RS15545 Protein ID WP_060085317.1
Coordinates 2028041..2028337 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID A0A806V1K0
Locus tag MW307_RS15550 Protein ID WP_027791641.1
Coordinates 2028340..2028741 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MW307_RS15530 2024573..2026123 + 1551 WP_119338602.1 sensor domain-containing diguanylate cyclase -
MW307_RS15535 2026367..2026642 + 276 WP_060207255.1 hypothetical protein -
MW307_RS15540 2026897..2027937 + 1041 WP_027791639.1 succinylglutamate desuccinylase/aspartoacylase family protein -
MW307_RS15545 2028041..2028337 + 297 WP_060085317.1 type II toxin-antitoxin system MqsR family toxin Toxin
MW307_RS15550 2028340..2028741 + 402 WP_027791641.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
MW307_RS15555 2029059..2029619 + 561 WP_027791642.1 GNAT family N-acetyltransferase -
MW307_RS15560 2029676..2030623 + 948 WP_059588816.1 ABC transporter substrate-binding protein -
MW307_RS15565 2030687..2031736 + 1050 WP_119338601.1 LLM class flavin-dependent oxidoreductase -
MW307_RS15570 2031744..2033096 + 1353 WP_060371962.1 LLM class flavin-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(74-127)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11207.04 Da        Isoelectric Point: 8.0535

>T242056 WP_060085317.1 NZ_CP095497:2028041-2028337 [Burkholderia cepacia]
MEKRRPHCKLTLVKALVESGQVRLTASAVLGARQLGFTEREALDVVMSLTDLDFHKSMTTYADHTIWQDVYRPLTVRGDV
YLKLTVIDDVLIVSFKER

Download         Length: 297 bp

>T242056 NZ_OV049808:4279198-4279300 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14549.82 Da        Isoelectric Point: 8.8305

>AT242056 WP_027791641.1 NZ_CP095497:2028340-2028741 [Burkholderia cepacia]
MKCPACGAAKLVRDTRDIPYTYKGRSTVVRAVTGEFCPACGESVLDLDEATRLGEAISEFNKQVNATIVDPNYIAKVRKK
LKLDQREAAELFGGGVNAFSRYETGKTNPPLALVKLLKILDRHPDLLAEVRAA

Download         Length: 402 bp

>AT242056 NZ_OV049808:c4279307-4279162 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S5DDW5

Antitoxin

Source ID Structure
AlphaFold DB A0A806V1K0

References