Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 65841..66094 | Replicon | plasmid pIM057_KPC |
| Accession | NZ_CP095423 | ||
| Organism | Klebsiella pneumoniae strain IM057 | ||
Toxin (Protein)
| Gene name | srnB | Uniprot ID | G9G1E3 |
| Locus tag | MWR70_RS28805 | Protein ID | WP_001312851.1 |
| Coordinates | 65841..65990 (-) | Length | 50 a.a. |
Antitoxin (RNA)
| Gene name | srnC | ||
| Locus tag | - | ||
| Coordinates | 66035..66094 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MWR70_RS28770 (61200) | 61200..61615 | - | 416 | Protein_83 | IS1-like element IS1B family transposase | - |
| MWR70_RS28775 (61864) | 61864..62265 | - | 402 | WP_001398199.1 | type II toxin-antitoxin system toxin endoribonuclease PemK | - |
| MWR70_RS28780 (62198) | 62198..62455 | - | 258 | WP_000557619.1 | type II toxin-antitoxin system antitoxin PemI | - |
| MWR70_RS28785 (62548) | 62548..63201 | - | 654 | WP_000616807.1 | CPBP family intramembrane metalloprotease | - |
| MWR70_RS28790 (64140) | 64140..64997 | - | 858 | WP_142295464.1 | incFII family plasmid replication initiator RepA | - |
| MWR70_RS28795 (64990) | 64990..65064 | - | 75 | WP_001375168.1 | RepA leader peptide Tap | - |
| MWR70_RS28800 (65309) | 65309..65557 | - | 249 | WP_000083837.1 | replication regulatory protein RepA | - |
| MWR70_RS28805 (65841) | 65841..65990 | - | 150 | WP_001312851.1 | Hok/Gef family protein | Toxin |
| - (66035) | 66035..66094 | + | 60 | NuclAT_1 | - | Antitoxin |
| - (66035) | 66035..66094 | + | 60 | NuclAT_1 | - | Antitoxin |
| - (66035) | 66035..66094 | + | 60 | NuclAT_1 | - | Antitoxin |
| - (66035) | 66035..66094 | + | 60 | NuclAT_1 | - | Antitoxin |
| MWR70_RS28810 (66295) | 66295..66627 | - | 333 | WP_152916585.1 | hypothetical protein | - |
| MWR70_RS28815 (66689) | 66689..67288 | - | 600 | WP_032083981.1 | PIN domain-containing protein | - |
| MWR70_RS28820 (67674) | 67674..67874 | - | 201 | WP_015059022.1 | hypothetical protein | - |
| MWR70_RS28825 (68006) | 68006..68566 | - | 561 | WP_000139328.1 | fertility inhibition protein FinO | - |
| MWR70_RS28830 (68621) | 68621..69367 | - | 747 | WP_000205770.1 | conjugal transfer pilus acetylase TraX | - |
| MWR70_RS28835 (69387) | 69387..69587 | - | 201 | WP_072354025.1 | hypothetical protein | - |
| MWR70_RS28840 (69612) | 69612..70316 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| MWR70_RS28845 (70369) | 70369..70434 | + | 66 | Protein_98 | helix-turn-helix domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | blaKPC-2 / blaSHV-12 / rmtB / blaTEM-1B / blaCTX-M-65 / catA2 | - | 1..129505 | 129505 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5542.67 Da Isoelectric Point: 8.7678
>T241943 WP_001312851.1 NZ_CP095423:c65990-65841 [Klebsiella pneumoniae]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
Download Length: 150 bp
>T241943 NZ_OU701452:c957861-957475 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA
Antitoxin
Download Length: 60 bp
>AT241943 NZ_CP095423:66035-66094 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
