Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2607..3192 Replicon plasmid pTCM-2
Accession NZ_CP095409
Organism Acinetobacter pittii strain TCM

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MWH18_RS21520 Protein ID WP_199953181.1
Coordinates 2607..2927 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MWH18_RS21525 Protein ID WP_094069338.1
Coordinates 2920..3192 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MWH18_RS21510 (MWH18_21505) 622..1482 - 861 WP_199953179.1 restriction endonuclease -
MWH18_RS21515 (MWH18_21510) 1669..2448 - 780 WP_199953180.1 pentapeptide repeat-containing protein -
MWH18_RS21520 (MWH18_21515) 2607..2927 + 321 WP_199953181.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MWH18_RS21525 (MWH18_21520) 2920..3192 + 273 WP_094069338.1 NadS family protein Antitoxin
MWH18_RS21530 (MWH18_21525) 3676..3993 - 318 WP_005065053.1 hypothetical protein -
MWH18_RS21535 (MWH18_21530) 4331..4855 - 525 WP_005127114.1 plasmid replication DNA-binding protein -
MWH18_RS21540 (MWH18_21535) 4934..5863 - 930 WP_005133531.1 replication initiation protein RepM -
MWH18_RS21545 (MWH18_21540) 7270..7461 + 192 WP_000102616.1 hypothetical protein -
MWH18_RS21550 (MWH18_21545) 7504..7902 - 399 WP_024437500.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..11346 11346


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-85)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12223.04 Da        Isoelectric Point: 7.9835

>T241913 WP_199953181.1 NZ_CP095409:2607-2927 [Acinetobacter pittii]
MLFIETSIFTKQIKELVSDEEYRQLQQDLLVQPDKGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLIAY
PKSVKDNLTDKETSILRQLVKEQFHG

Download         Length: 321 bp

>T241913 NZ_OU659204:c3850065-3849778 [Providencia alcalifaciens]
ATGAGTATTAAAATAAAAGAGTATGACATTGCTGAGCATTTAACGAACGAAGAAGAAATTCAGCTGTATCTTAATGAAAT
ACTAGAAGAAGGCGATACGGCACTCATTCTTGCTGCATTAGGCGATATTGCGAGAGCGAGAAATATGACCCAATTAGCAA
AGGAAGTGGGCATGAGCCGAGAAGGGCTATATAAGGCACTATCTGGTGAAGGTAACCCTGCATTTACCACTATCTTGAAG
ATAGTTCATTCACTCGGACTAAAGCTGCAATTTAAGAGCGCAAGATAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10108.56 Da        Isoelectric Point: 7.2045

>AT241913 WP_094069338.1 NZ_CP095409:2920-3192 [Acinetobacter pittii]
MDNNLFDDLVASIKEAGAIKRNELKASRVTELELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILDAHPTLI

Download         Length: 273 bp

>AT241913 NZ_OU659204:c3850364-3850062 [Providencia alcalifaciens]
ATGTTGACCGTACTAACGACAGATATCTTTAATAGATGGATGCATGACCTGAAAGATATTCGAGCAAAAACAAAGATTCA
GGTAAGAATTCGGCGTTTGAAACAAGGCAATTTTGGTGATGTCGAACCGATAGGTGATGGTTTTTCTGAATTAAAAATAC
ATGAAGGGAAAGGATATCGCGTTTATTTAAGAAAGATTGATAATACAATCGTATTGTTAATTAGTGGTGGTGATAAATCA
ACGCAGCAAAAAGATATCGACAAAGCCAAACAAATTTTTCGTGAAATTGAAGGTGATCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References