Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 27460..28111 | Replicon | plasmid pTCM-1 |
| Accession | NZ_CP095408 | ||
| Organism | Acinetobacter pittii strain TCM | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A7H2WXC0 |
| Locus tag | MWH18_RS21145 | Protein ID | WP_006581604.1 |
| Coordinates | 27755..28111 (-) | Length | 119 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | MWH18_RS21140 | Protein ID | WP_001140619.1 |
| Coordinates | 27460..27762 (-) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MWH18_RS21085 (MWH18_21080) | 22533..22988 | + | 456 | WP_001136773.1 | hypothetical protein | - |
| MWH18_RS21090 (MWH18_21085) | 23049..23516 | + | 468 | WP_002123983.1 | hypothetical protein | - |
| MWH18_RS21095 (MWH18_21090) | 23554..23781 | + | 228 | WP_029769069.1 | hypothetical protein | - |
| MWH18_RS21100 (MWH18_21095) | 24065..24354 | - | 290 | Protein_32 | helix-turn-helix domain-containing protein | - |
| MWH18_RS21105 (MWH18_21100) | 24341..24562 | - | 222 | Protein_33 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| MWH18_RS21110 (MWH18_21105) | 24806..25126 | - | 321 | WP_002123990.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| MWH18_RS21115 (MWH18_21110) | 25312..25440 | + | 129 | WP_002123981.1 | AAA family ATPase | - |
| MWH18_RS21120 (MWH18_21115) | 25494..25700 | + | 207 | WP_233728806.1 | AAA family ATPase | - |
| MWH18_RS21125 (MWH18_21120) | 25628..26173 | + | 546 | Protein_37 | IS5-like element ISAba13 family transposase | - |
| MWH18_RS21130 (MWH18_21125) | 26930..27148 | + | 219 | WP_029747731.1 | hypothetical protein | - |
| MWH18_RS21135 (MWH18_21130) | 27258..27467 | - | 210 | WP_000069471.1 | hypothetical protein | - |
| MWH18_RS21140 (MWH18_21135) | 27460..27762 | - | 303 | WP_001140619.1 | XRE family transcriptional regulator | Antitoxin |
| MWH18_RS21145 (MWH18_21140) | 27755..28111 | - | 357 | WP_006581604.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| MWH18_RS21150 (MWH18_21145) | 28732..29604 | - | 873 | WP_006581603.1 | restriction endonuclease | - |
| MWH18_RS21155 (MWH18_21150) | 29808..30089 | - | 282 | WP_000985610.1 | putative addiction module antidote protein | - |
| MWH18_RS21160 (MWH18_21155) | 30090..30392 | - | 303 | WP_000286963.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| MWH18_RS21165 (MWH18_21160) | 30584..30976 | + | 393 | WP_228713465.1 | hypothetical protein | - |
| MWH18_RS21170 (MWH18_21165) | 30988..31920 | - | 933 | WP_002048759.1 | IS5 family transposase | - |
| MWH18_RS21175 (MWH18_21170) | 31974..32453 | + | 480 | Protein_47 | GIY-YIG nuclease family protein | - |
| MWH18_RS21180 (MWH18_21175) | 32653..33015 | - | 363 | Protein_48 | plasmid replication DNA-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | sul2 | - | 1..84108 | 84108 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 119 a.a. Molecular weight: 13462.38 Da Isoelectric Point: 7.1642
>T241911 WP_006581604.1 NZ_CP095408:c28111-27755 [Acinetobacter pittii]
MWTVITTDLFNEWLAQQDQSTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKDLRVQHRGKSLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYEIHLSTLGDQSNG
MWTVITTDLFNEWLAQQDQSTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKDLRVQHRGKSLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYEIHLSTLGDQSNG
Download Length: 357 bp
>T241911 NZ_OU659204:c2708163-2707753 [Providencia alcalifaciens]
GTGGTCCTGTGGAAATCTAATCTTTCCATTTCATGGAAAACTCAGCTTTTTTCTACCTGCCTTCATGGGGTAACGGGCAT
TATTTTGCTTGTTGCGCCATGGGCTCCAGGTAATTCAATGATTTGGCTACCATTATTAGTTGTGTTGGTAGCAAGTTGGG
CAAAAAGCCAAAAAAATATCAGTAAAGTCAAAGGTGTGGCTGTATTGGTGAATGGCAACAAGCTTCAATGGAAAAAGAAT
GAGTGGGAAATTATTAAAGCGCCATGGTGTAGCCGCTTTGGCATTTTATTAACGCTTAATGCGCTGCAAGGTAAGCCTCA
GAAGCTTCGCTTGTGGATTGCAAAGGATTCTGTTTGTGAAGAGAATTGGCGCAATCTCAATCAATTACTACTGCAATATC
CTGATATTTGA
GTGGTCCTGTGGAAATCTAATCTTTCCATTTCATGGAAAACTCAGCTTTTTTCTACCTGCCTTCATGGGGTAACGGGCAT
TATTTTGCTTGTTGCGCCATGGGCTCCAGGTAATTCAATGATTTGGCTACCATTATTAGTTGTGTTGGTAGCAAGTTGGG
CAAAAAGCCAAAAAAATATCAGTAAAGTCAAAGGTGTGGCTGTATTGGTGAATGGCAACAAGCTTCAATGGAAAAAGAAT
GAGTGGGAAATTATTAAAGCGCCATGGTGTAGCCGCTTTGGCATTTTATTAACGCTTAATGCGCTGCAAGGTAAGCCTCA
GAAGCTTCGCTTGTGGATTGCAAAGGATTCTGTTTGTGAAGAGAATTGGCGCAATCTCAATCAATTACTACTGCAATATC
CTGATATTTGA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11206.01 Da Isoelectric Point: 6.7282
>AT241911 WP_001140619.1 NZ_CP095408:c27762-27460 [Acinetobacter pittii]
MAKTLQELLANRSPESQARIQQMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV
MAKTLQELLANRSPESQARIQQMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV
Download Length: 303 bp
>AT241911 NZ_OU659204:c2708410-2708144 [Providencia alcalifaciens]
ATCGATATCAATAACAAGGCGCGAATTCATTGGGCGTGCAGAAGAGGCATGCGTGAGCTTGATATTTCTATCATGCCATT
TTTTGAATATGAATATGACGAGCTAACAGACCACGACAAGCGTGTTTTTGTGCGCCTGCTCGAATGCCCAGACCCGGATT
TGTTCAATTGGCTGATGAATCACGGGCGTCCAGAGGACGAAGAACTGTTCTCTATGATTAAACTCATTCAAGAAAGAAAT
AAAAATCGTGGTCCTGTGGAAATCTAA
ATCGATATCAATAACAAGGCGCGAATTCATTGGGCGTGCAGAAGAGGCATGCGTGAGCTTGATATTTCTATCATGCCATT
TTTTGAATATGAATATGACGAGCTAACAGACCACGACAAGCGTGTTTTTGTGCGCCTGCTCGAATGCCCAGACCCGGATT
TGTTCAATTGGCTGATGAATCACGGGCGTCCAGAGGACGAAGAACTGTTCTCTATGATTAAACTCATTCAAGAAAGAAAT
AAAAATCGTGGTCCTGTGGAAATCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|