Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | DinJ-YafQ (relBE)/YafQ-DinJ |
| Location | 132058..132622 | Replicon | chromosome |
| Accession | NZ_CP095406 | ||
| Organism | Lacticaseibacillus paracasei strain GM-080 | ||
Toxin (Protein)
| Gene name | yafQ | Uniprot ID | A0A6G9EML4 |
| Locus tag | MWH19_RS00810 | Protein ID | WP_014951859.1 |
| Coordinates | 132320..132622 (+) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | dinJ | Uniprot ID | K6SLT0 |
| Locus tag | MWH19_RS00805 | Protein ID | WP_003570051.1 |
| Coordinates | 132058..132327 (+) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MWH19_RS00775 (MWH19_00765) | 127062..127949 | - | 888 | WP_012491506.1 | ABC transporter ATP-binding protein | - |
| MWH19_RS00780 (MWH19_00770) | 128147..129373 | - | 1227 | WP_012491507.1 | hypothetical protein | - |
| MWH19_RS00785 (MWH19_00775) | 129571..129975 | + | 405 | WP_012491508.1 | MerR family transcriptional regulator | - |
| MWH19_RS00790 (MWH19_00780) | 129968..130294 | + | 327 | WP_012491509.1 | YrdB family protein | - |
| MWH19_RS00795 (MWH19_00785) | 130357..130986 | + | 630 | WP_012491510.1 | DUF2399 domain-containing protein | - |
| MWH19_RS00800 (MWH19_00790) | 131031..131684 | + | 654 | WP_283544572.1 | N-acetyltransferase | - |
| MWH19_RS00805 (MWH19_00795) | 132058..132327 | + | 270 | WP_003570051.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| MWH19_RS00810 (MWH19_00800) | 132320..132622 | + | 303 | WP_014951859.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
| MWH19_RS00815 (MWH19_00805) | 132961..133104 | + | 144 | WP_003574774.1 | hypothetical protein | - |
| MWH19_RS00820 (MWH19_00810) | 133222..133914 | + | 693 | WP_012491513.1 | hypothetical protein | - |
| MWH19_RS00825 (MWH19_00815) | 134150..136327 | + | 2178 | WP_012491514.1 | Tex family protein | - |
| MWH19_RS00830 (MWH19_00820) | 136392..137321 | - | 930 | WP_003599410.1 | IS30-like element ISLpl1 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 136392..137321 | 929 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11441.27 Da Isoelectric Point: 10.2818
>T241905 WP_014951859.1 NZ_CP095406:132320-132622 [Lacticaseibacillus paracasei]
MYSLVPTPTFKRDLKRLSKKHWPMDELKTAVNLLAAGTNAELLSKKYADHALSSSSEWKGYRELHVDGPRGDWLLIYKIK
QQDLILTLVRTGSHHNLLGK
MYSLVPTPTFKRDLKRLSKKHWPMDELKTAVNLLAAGTNAELLSKKYADHALSSSSEWKGYRELHVDGPRGDWLLIYKIK
QQDLILTLVRTGSHHNLLGK
Download Length: 303 bp
>T241905 NZ_OU659204:c555914-555411 [Providencia alcalifaciens]
ATGCATCTAGCCATTACAGGCCTGTATCAAGCAAAATGGACCGATACTATTCAAGACGAATGGCAGCGGAATCTACTCAG
TAACCGTCCTGATTTAGCCCAAAAACAGTTAATCCGAACGGCCTCACTAATGAATAATGCGCTACCAGACGCTAGAGTCA
GTCAATATGAACCATTAATTGAAGGTATTGAATTGCCCGACCTTAATGACCGGCATGTTGTTGCTGCAGCCATAAAATGC
CATGCAAAAATCATTGTGACGCTCAATCTAAAAGATTTTCCAAAAGAATCTATGGATCAATTAGAAATAGAAGCCTTGCA
TCCAGATGAGTTTATTTCAGACTTATTTGATTTAAACCATGCTCTGGCTTTATCCGCTGTGCGCCGACAACGACTCAGCT
TAACAAAGCCAGAAATAAATATTAACGAGTACTTTGCCGCCTTGTTACGCCAAGGATTGCCGATGACAGTCAAAGCACTC
GAAAAATACCAGAGCATGATTTGA
ATGCATCTAGCCATTACAGGCCTGTATCAAGCAAAATGGACCGATACTATTCAAGACGAATGGCAGCGGAATCTACTCAG
TAACCGTCCTGATTTAGCCCAAAAACAGTTAATCCGAACGGCCTCACTAATGAATAATGCGCTACCAGACGCTAGAGTCA
GTCAATATGAACCATTAATTGAAGGTATTGAATTGCCCGACCTTAATGACCGGCATGTTGTTGCTGCAGCCATAAAATGC
CATGCAAAAATCATTGTGACGCTCAATCTAAAAGATTTTCCAAAAGAATCTATGGATCAATTAGAAATAGAAGCCTTGCA
TCCAGATGAGTTTATTTCAGACTTATTTGATTTAAACCATGCTCTGGCTTTATCCGCTGTGCGCCGACAACGACTCAGCT
TAACAAAGCCAGAAATAAATATTAACGAGTACTTTGCCGCCTTGTTACGCCAAGGATTGCCGATGACAGTCAAAGCACTC
GAAAAATACCAGAGCATGATTTGA
Antitoxin
Download Length: 90 a.a. Molecular weight: 9982.68 Da Isoelectric Point: 7.2026
>AT241905 WP_003570051.1 NZ_CP095406:132058-132327 [Lacticaseibacillus paracasei]
MAATKKETRLNIRVDPELKSAAQIVANDMGIDLTAAVTMFMTKMVKDHALPFTPTSLPVETLQALKEAKHPELLKKYSTP
DDMWRDLNV
MAATKKETRLNIRVDPELKSAAQIVANDMGIDLTAAVTMFMTKMVKDHALPFTPTSLPVETLQALKEAKHPELLKKYSTP
DDMWRDLNV
Download Length: 270 bp
>AT241905 NZ_OU659204:c556447-555986 [Providencia alcalifaciens]
ATGACACACTCAATTCTTAATAGTATGAGCCTCCCGGCTCCAAAGGAGATTGAGGCGGCAGTACGCGGACAAAGAGAGCT
TGCAACTTATCTCTCCACTAAGTTAGAAACCCAGCAAATATCCATTAAAGATGCTGATGACAATATTCATCAAATTGAGT
TACCAACATCAGCACTCACATTGTTAATGGCTATTTTGGGTGAGCTAGCAGCAGGTAATGCAGTACAAGTTGTTCCCGTA
CATGCAGAGCTAACAACGCAGGAAGCGGCTAATATTCTTAATGTTTCTCGCCCACATATGGTGAAACTGCTAGAAGAAGG
TAGACTTCCTTTTCATAAAACAGGTCGTCATCGCCGTATTCTTTTTGCAGATTTAATGCAATTCAAAGCTCAACGAGAGA
AAGAGAGCTTACAGGCAATGCAAGCGCTGGTAGACCAAAGTCAGGAGCTTGGTCTTTACTGA
ATGACACACTCAATTCTTAATAGTATGAGCCTCCCGGCTCCAAAGGAGATTGAGGCGGCAGTACGCGGACAAAGAGAGCT
TGCAACTTATCTCTCCACTAAGTTAGAAACCCAGCAAATATCCATTAAAGATGCTGATGACAATATTCATCAAATTGAGT
TACCAACATCAGCACTCACATTGTTAATGGCTATTTTGGGTGAGCTAGCAGCAGGTAATGCAGTACAAGTTGTTCCCGTA
CATGCAGAGCTAACAACGCAGGAAGCGGCTAATATTCTTAATGTTTCTCGCCCACATATGGTGAAACTGCTAGAAGAAGG
TAGACTTCCTTTTCATAAAACAGGTCGTCATCGCCGTATTCTTTTTGCAGATTTAATGCAATTCAAAGCTCAACGAGAGA
AAGAGAGCTTACAGGCAATGCAAGCGCTGGTAGACCAAAGTCAGGAGCTTGGTCTTTACTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6G9EML4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E2BRK6 |