241903

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2710205..2710727 Replicon chromosome
Accession NZ_CP095384
Organism Lacticaseibacillus rhamnosus strain VHProbi M14

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag MU539_RS12760 Protein ID WP_033571956.1
Coordinates 2710467..2710727 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag MU539_RS12755 Protein ID WP_033571955.1
Coordinates 2710205..2710474 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU539_RS12735 (MU539_12710) 2706126..2706695 - 570 WP_005687747.1 PTS glucitol/sorbitol transporter subunit IIC -
MU539_RS12740 (MU539_12715) 2706708..2707217 - 510 WP_005712202.1 transcriptional regulator GutM -
MU539_RS12745 (MU539_12720) 2707218..2709086 - 1869 WP_033571953.1 HTH domain-containing protein -
MU539_RS12750 (MU539_12725) 2709113..2709913 - 801 WP_033571954.1 SDR family oxidoreductase -
MU539_RS12755 (MU539_12730) 2710205..2710474 + 270 WP_033571955.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
MU539_RS12760 (MU539_12735) 2710467..2710727 + 261 WP_033571956.1 Txe/YoeB family addiction module toxin Toxin
MU539_RS12765 (MU539_12740) 2710938..2711666 - 729 WP_033571957.1 L-ribulose-5-phosphate 4-epimerase -
MU539_RS12770 (MU539_12745) 2711863..2712684 + 822 WP_005687759.1 Cof-type HAD-IIB family hydrolase -
MU539_RS12775 (MU539_12750) 2712751..2713638 - 888 WP_033571958.1 L-ribulose-5-phosphate 3-epimerase -
MU539_RS12780 (MU539_12755) 2713823..2714602 - 780 WP_191979940.1 DeoR/GlpR family DNA-binding transcription regulator -
MU539_RS12785 (MU539_12760) 2714670..2715311 - 642 WP_005687764.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10428.86 Da        Isoelectric Point: 9.6577

>T241903 WP_033571956.1 NZ_CP095384:2710467-2710727 [Lacticaseibacillus rhamnosus]
MIKTWTDDAWADYMYWHDQNDKRTIKRINQLIQAIDRDPYKGIGKPEPLRYALTGKWSRRIDQENRIIYSIEKGHINIFA
CRTHYS

Download         Length: 261 bp

>T241903 NZ_OU659164:74199-75143 [Providencia alcalifaciens]
ATGGATAGAGACAGTCCTTACTATAAGCAAGTTTCTCTGCTTATTAAAATACTACCCGTCATAGCAACAGAGCCAACATT
CGCACTTAAAGGCGGCACTGCTATAAATTTATTTGTGAGGAATTTTCCTCGTCTATCAGTAGATATTGATCTCGCCTATC
TTCCATTAGAGTCCAGAAATGATGCACTAGTAAATGTTAAAGCTTCGCTTCTACGGATCACTGATTTAATTAATACTCAA
GTTGATACTCGGGCTGTGTTACAAGACCATAAAGTCGATGAGCTTCGTATTATTGTTAATAGCCCAGGTGGCACTATAAA
GGTTGAGGTATCTCCCGTTGCTAGAGGAGCTTTACATCAACCGAGCATTTTATCCGTACAACCGTCAGTTGAAGATGAAT
TTGGCTATGCAGAAATTCAAGTGGTTAGCCTCCCTGATCTCTATGGCGGTAAGTTATGCGCTGCAATGGATCGCCAACAT
CCTCGCGATTTGTTTGATGTTCGTATGTTGCTTGCAGAGGAGGGAATATCCCGAGATATTTTTGTCGGTTTTTTAACTTA
TGTACTAAGTCATCCAAGACCGATTAATGAGGTTATGGATCCTAACTGGAAGCCACTTGATGAGATATTTCAAACAGAAT
TTGATGGAATGACTTTGGTCAACATTGAACTTGAAGATTTGATTGAGGTAAGATCTGCAATGATGACTGCATTACAGGCT
CATTTCACTGAAAAAGATCGCGTATTTTTGTTATCTTTTAAGCAAGGAAACCCTGATTGGGCACTATTTGACTATCCTAG
TGCTGAAGGGTTGCCAGCAATACGTTGGAAATTACAAAATATCGCGCAATTAGCTAAAAATCGGGATAAATATACAGAGC
AGCTATCTAAATTAGAGGTGGTGCTTGATAGGTGGCTTCACTCAGCGGATAAACAGAGATTGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10181.39 Da        Isoelectric Point: 4.6755

>AT241903 WP_033571955.1 NZ_CP095384:2710205-2710474 [Lacticaseibacillus rhamnosus]
MEATNYSNFRRNLKHYMSQVNEDAEPLLVTAKDDDDDVVVMSKHDFDAIEETLYLLSNPKLMAKIKRGDAQIAAGKAKQH
ELLTDFDHD

Download         Length: 270 bp

>AT241903 NZ_OU659164:73415-74185 [Providencia alcalifaciens]
ATGTCATCTAAAATAAACTGGTTGGTTACTCATACATATCCAGGCTCGATTGTTTTACAGCAATGGCTGACTAAGAACGG
GATAAGTTACTCCTTAGCTCAAAAGTATACGCAAAGTGGCTGGCTGAAAAAGTTATCTTCAGGTGTTTACTTCCGACCTG
ATGGAAAAGATGGCACCAAACCAGATTGGGTCGATGCCTTGCAAGCGATAAATATTCAGCAGTGTCTTCCTGTTCATTTG
GCGGGATTAAGTAGTTTAAATCACCAAGGATTGAGCCATTATCTACAGCTAAGAAAAGAACAGCTTTGGATTGGCATTAA
AAGTAAGCAGTCATTACCAAAATGGTTTCGAGAGTTTCCTAACCAAGATTGGTTTTATTGTGGTAATTCTAAATTGCAAA
TAGACCCTGACATGGATTTGAAATTCATTACAGTTAAAGGAAAAGAGTTGCTAGTCAGTCGTTCTGAACTTGCGGCTTAT
GAAGTTGTTGATGCAATAGGTAAGCAAATATCGTTTGAGCATGTTGCTGAGCTTTTTCAAGGGCTAGTAAACCTTAGTCC
TAAAAGGGTGCAATCCTTACTTGAGCGAAGTCATGCCATTCAAACCAACCGAATATTCTTGTTTCTTAGTCATCACTGCG
ACCATCAATGGGGAGAATACCTTAATGAAAAAAACATCGAATTAGGATCAGGAAAGCGCCAGGTTGTAAATAAAGGTCGG
CTTGATGAGCGTTATCAAATCACTGTGCCTGAATCACTGAAGACAAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References