Detailed information of TA system TA241898

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 9287838..9288337
• Replicon: chromosome
• Accession: NZ_CP095376
• Organism: Amycolatopsis pretoriensis strain FBCC-B4732

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: MUY14_RS42250
• Protein ID: WP_247018192.1
• Coordinates: 9287838..9288098 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: MUY14_RS42255
• Protein ID: WP_229907886.1
• Coordinates: 9288095..9288337 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUY14_RS42225 (MUY14_42225)	9283198..9283878	-	681	WP_247018185.1	DUF2064 domain-containing protein	-
MUY14_RS42230 (MUY14_42230)	9283875..9284519	-	645	WP_247025501.1	glycosyltransferase family 2 protein	-
MUY14_RS42235 (MUY14_42235)	9284678..9286078	+	1401	WP_247018187.1	hypothetical protein	-
MUY14_RS42240 (MUY14_42240)	9286089..9286790	+	702	WP_247018189.1	response regulator transcription factor	-
MUY14_RS42245 (MUY14_42245)	9286787..9287836	+	1050	WP_247018190.1	HAMP domain-containing sensor histidine kinase	-
MUY14_RS42250 (MUY14_42250)	9287838..9288098	-	261	WP_247018192.1	Txe/YoeB family addiction module toxin	Toxin
MUY14_RS42255 (MUY14_42255)	9288095..9288337	-	243	WP_229907886.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
MUY14_RS42260 (MUY14_42260)	9288451..9289512	-	1062	WP_247018194.1	NAD-dependent epimerase/dehydratase family protein	-
MUY14_RS42265 (MUY14_42265)	9289636..9290136	+	501	WP_086861534.1	MogA/MoaB family molybdenum cofactor biosynthesis protein	-
MUY14_RS42270 (MUY14_42270)	9290212..9290385	+	174	WP_247018196.1	hypothetical protein	-
MUY14_RS42275 (MUY14_42275)	9290392..9290805	-	414	WP_086678717.1	large-conductance mechanosensitive channel protein MscL	-
MUY14_RS42280 (MUY14_42280)	9290835..9291461	-	627	WP_247018198.1	SAF domain-containing protein	-
MUY14_RS42285 (MUY14_42285)	9291593..9291904	-	312	WP_247018200.1	zinc ribbon domain-containing protein	-
MUY14_RS42290 (MUY14_42290)	9291991..9292581	-	591	WP_247018202.1	5-formyltetrahydrofolate cyclo-ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-70)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10481.96 Da
• Isoelectric Point: 8.8669

>T241898 WP_247018192.1 NZ_CP095376:c9288098-9287838 [Amycolatopsis pretoriensis]
MKLVWDELAWHDYLWWQTEDRKVLKRINALLEDVRRNGNEGLGKPEPLKHGFQGYWSRRITDEHRLVYKIAEDEIRIAAC
RYHYGK

Nucleotide

• Length: 261 bp

>T241898 NZ_OU659163:c53300-53022 [Providencia alcalifaciens]
ATGATAAAATCGTTTAAACATAAAGGGTTGAAACAACTCTTTGAAAAAGGAATAACTTCAGGGGTTCCGGCTCAAGATGC
TGAACGGATCAACGACCGTTTACAAGCAATAGATATCGCTAACGATATTCGTGAATTAGACCGCCAAATTTACAAATTGC
ATCCACTGAAAGGTGACAGAGAAGGTTATTGGTCAATAACAGTGCGAGCGAATTGGCGCATTACTTTTCAATTCATCAAT
GGTGATGCTTACATCTTAAATTATGAGGATTATCACTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8992.99 Da
• Isoelectric Point: 4.5038

>AT241898 WP_229907886.1 NZ_CP095376:c9288337-9288095 [Amycolatopsis pretoriensis]
MSYSESRAKYAETLDSVVNDREEVVITRAGHEPVVIVSLDDYQSLKETAYLLRSPENARRLITAIERLESGGGTQHELVE

Nucleotide

• Length: 243 bp

>AT241898 NZ_OU659163:c53022-52708 [Providencia alcalifaciens]
ATGAGACAGTTTAAAATATCTCACCCAGGTGAAATTATTGCACGAGATTTGGCTGATATGGGGATCAGTGGTCGACGTTT
TGCATTAAATATTGGTGTAACGCCAGCAACAGTTTCCCGTTTTTTATCAGGTAAAACAGCATTGACTCCCGCATTGGCAA
TCCGTATCGCCGCTGCACTAGGAAGTACTCCTGAATTTTGGTTACGTTTACAAAGTGCTTATGATTTACGTCAATTAGAA
AATCAAATTGATACGTCCGATATTATTTTGTATGAAGAGGCGCCTGATAGCGCTAAAGGCATATCCAAACATTAG