Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 8848355..8849096 Replicon chromosome
Accession NZ_CP095376
Organism Amycolatopsis pretoriensis strain FBCC-B4732

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MUY14_RS40035 Protein ID WP_247017473.1
Coordinates 8848355..8848720 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MUY14_RS40040 Protein ID WP_247017475.1
Coordinates 8848725..8849096 (+) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUY14_RS40020 (MUY14_40020) 8843927..8844493 + 567 WP_247017467.1 TIGR03086 family metal-binding protein -
MUY14_RS40025 (MUY14_40025) 8844403..8845320 - 918 WP_247017469.1 (2Fe-2S)-binding protein -
MUY14_RS40030 (MUY14_40030) 8845690..8848248 + 2559 WP_247017471.1 ATP-dependent Clp protease ATP-binding subunit -
MUY14_RS40035 (MUY14_40035) 8848355..8848720 + 366 WP_247017473.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MUY14_RS40040 (MUY14_40040) 8848725..8849096 + 372 WP_247017475.1 XRE family transcriptional regulator Antitoxin
MUY14_RS40045 (MUY14_40045) 8849151..8850341 + 1191 Protein_7959 Hsp70 family protein -
MUY14_RS40050 (MUY14_40050) 8850373..8850831 - 459 WP_247017477.1 YbaB/EbfC family nucleoid-associated protein -
MUY14_RS40055 (MUY14_40055) 8850824..8851882 - 1059 WP_247017479.1 hypothetical protein -
MUY14_RS40060 (MUY14_40060) 8851884..8852264 - 381 WP_247017481.1 hypothetical protein -
MUY14_RS40065 (MUY14_40065) 8852399..8853061 + 663 WP_247017483.1 hypothetical protein -
MUY14_RS40070 (MUY14_40070) 8853058..8853699 - 642 WP_247025477.1 pyroglutamyl-peptidase I -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(22-111)

Antitoxin

HigA2-like, helix-turn-helix domain

(21-98)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 5.6002

>T241897 WP_247017473.1 NZ_CP095376:8848355-8848720 [Amycolatopsis pretoriensis]
MEWEIELHDEVDRWFVDLCRTDPVSADRVEEAIDVLAREGPGLGRPLVDRVHGSRLHNLKELRPASAGASEIRILFAFDP
VRRAVLLVAGDKAGNWKGWYDRNIPVAELRFREHLSHGAEG

Download         Length: 366 bp

>T241897 NZ_OU659162:c2845719-2845309 [Providencia alcalifaciens]
GTGGTCCTGTGGAAATCTAATCTTTCCATTTCATGGAAAACCCAGCTTTTTTCAACCAGCCTCCATGTGGGGGCGGGTAT
CATTTTGCTTGTTGCACCATGGGAACCTGGTAACTCGATGATTTGGCTTCCATTATTGGTTATCTTAGTGGCGAGCTGGG
CAAAAAGTCAAAAGAACATTAGCAAAGTGAAAGGCGTTGCTGTACTGGTGAATGGCAATAAGCTTCAATGGAAAAAGAAT
GAGTGGGAAATAATCAAAGCACCATGGTGTAGCCGTTGTGGTATTTTATTGACGCTTAAGGCACTGCAAGGAAAGCCACA
GAAGCTGCGTTTGTGGGTGGCGAAAGATTCAGTGTCCGAAGAAAATTGGCGTAACCTCAATCAATTATTACTGCAATATC
CCGACATTTGA

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13123.69 Da        Isoelectric Point: 4.9463

>AT241897 WP_247017475.1 NZ_CP095376:8848725-8849096 [Amycolatopsis pretoriensis]
MSRSWKDVKADKAAIDRDAGRDVGGARAAAREATEAFVLGFRLAQLREDAGLSQTELAKRMGVSQPRISQLEQGDPGQME
LDTLRRYISALGGRLRVVADFDDHDVTVSAPAPEAAPEAGACA

Download         Length: 372 bp

>AT241897 NZ_OU659162:c2845966-2845700 [Providencia alcalifaciens]
ATCGATATCAATAACAAGGCGCGAATTCATTGGGCATGCAGAAGAGGCATGCGTGAGCTTGATATTTCTATCATGCCATT
TTTTGAATATGAATATGACGAACTGACAGATCACGATAAACGTATTTTTGTGCGTCTACTCGAGTGCCCAGATCCAGATT
TGTTCAATTGGTTGATGAATCACGGGCGTCCGGAGGATGAAGAGCTATTCTCTATGATTAAACTCATTCAAGAAAGAAAT
AAAAATCGTGGTCCTGTGGAAATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References