Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3732145..3732820 Replicon chromosome
Accession NZ_CP095276
Organism Enterobacter hormaechei subsp. xiangfangensis strain HD8642

Toxin (Protein)


Gene name higB Uniprot ID A0A837FDC1
Locus tag MU851_RS17860 Protein ID WP_015571638.1
Coordinates 3732145..3732444 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2J0PXC9
Locus tag MU851_RS17865 Protein ID WP_015571639.1
Coordinates 3732455..3732820 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU851_RS17850 (MU851_17820) 3728522..3730714 + 2193 WP_017692801.1 type I secretion system permease/ATPase -
MU851_RS17855 (MU851_17825) 3730695..3731894 + 1200 WP_017382757.1 HlyD family efflux transporter periplasmic adaptor subunit -
MU851_RS17860 (MU851_17830) 3732145..3732444 + 300 WP_015571638.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MU851_RS17865 (MU851_17835) 3732455..3732820 + 366 WP_015571639.1 HigA family addiction module antitoxin Antitoxin
MU851_RS17870 (MU851_17840) 3732847..3734028 - 1182 WP_015571640.1 PLP-dependent aminotransferase family protein -
MU851_RS17875 (MU851_17845) 3734049..3734936 - 888 WP_015571641.1 LysR family transcriptional regulator -
MU851_RS17880 (MU851_17850) 3735034..3735636 + 603 WP_017382759.1 short chain dehydrogenase -
MU851_RS17885 (MU851_17855) 3735633..3736364 - 732 WP_045349508.1 methyltransferase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(25-72)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11624.29 Da        Isoelectric Point: 9.6776

>T241886 WP_015571638.1 NZ_CP095276:3732145-3732444 [Enterobacter hormaechei subsp. xiangfangensis]
MINHFRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNMYEALSPPLKGYSSIRVNRQYRLVFRW
SEGKADDLYLSPHKYTQHK

Download         Length: 300 bp

>T241886 NZ_OU659132:123042-123323 [Providencia alcalifaciens]
ATGACTTATAAACTTGAATTTGATAGACGGGCGTTAAAAGAATGGCAAAAACTAGCCCCTCCGATTAGAAATCAATTTAA
AAAGAAACTGTTAGAACGTCTTGAAAATCCTTGTGTTCCATCAGCTAAACTTAGTGGTAAAAATAATCGTTATAAAATAA
AACTACGATCATTAGGTTACCGCTTAATTTATGAAGTGATAGATGAAAAAATTATTCTGTTAGTCATTGCCGTTGGTAAA
AGAGAGGGTAATACTGTCTATTTTTCATCGAACGAACGCTAA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13705.73 Da        Isoelectric Point: 9.5936

>AT241886 WP_015571639.1 NZ_CP095276:3732455-3732820 [Enterobacter hormaechei subsp. xiangfangensis]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEMLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWEAQSNSRTQEELSRIKTVAEVMAKRKSGKPDVTLHGNSA

Download         Length: 366 bp

>AT241886 NZ_OU659132:122801-123052 [Providencia alcalifaciens]
ATGACTTATCAAATTTTGAGTGATACTGCTGCGAGCATAACTGACTTGAAGAAAAATCCAATGGGCACTATTGCAGGTGG
TGAAGGGAACCCCGTAGCTATTCTTAATAGAAATGAACCTGCATTTTATTGTGTTCCCCCTGAACTATTTGCTTGGTTCA
TGGAGTTAGCTGAAGATGCTGAACTTAACAAAATTGCAGATGAACGATTAGAATCACTTGATGTAGTGAGTGTGAACATC
GATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FDC1

Antitoxin

Source ID Structure
AlphaFold DB A0A2J0PXC9

References