Detailed information of TA system TA241884

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 2992185..2992845
• Replicon: chromosome
• Accession: NZ_CP095276
• Organism: Enterobacter hormaechei subsp. xiangfangensis strain HD8642

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A2J0Q4X0
• Locus tag: MU851_RS14335
• Protein ID: WP_017383312.1
• Coordinates: 2992492..2992845 (-)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: MU851_RS14330
• Protein ID: WP_252055375.1
• Coordinates: 2992185..2992487 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MU851_RS14315 (MU851_14285)	2988359..2989684	+	1326	WP_017383315.1	SidA/IucD/PvdA family monooxygenase	-
MU851_RS14320 (MU851_14290)	2989711..2991900	+	2190	WP_252062577.1	TonB-dependent siderophore receptor	-
MU851_RS14330 (MU851_14300)	2992185..2992487	-	303	WP_252055375.1	XRE family transcriptional regulator	Antitoxin
MU851_RS14335 (MU851_14305)	2992492..2992845	-	354	WP_017383312.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MU851_RS14340 (MU851_14310)	2993036..2993986	-	951	WP_017383311.1	HTH-type transcriptional regulator Cbl	-
MU851_RS14345 (MU851_14315)	2994083..2995000	-	918	WP_003859531.1	nitrogen assimilation transcriptional regulator NAC	-
MU851_RS14355 (MU851_14325)	2995532..2996464	-	933	WP_048219824.1	L,D-transpeptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (33-79)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13537.37 Da
• Isoelectric Point: 9.9538

>T241884 WP_017383312.1 NZ_CP095276:c2992845-2992492 [Enterobacter hormaechei subsp. xiangfangensis]
VWAIKTTDRFDDWFTSLNDSERASVLAALLVLRERGPGLSRPYADTLKGSRHSNMKELRIQSKGDPLRAFFAFDPNRTGI
VLCAGNKVGNERRFYDEMLLVADREYTRWLNTLKERN

Nucleotide

• Length: 354 bp

>T241884 NZ_OU659130:c2357329-2356919 [Providencia alcalifaciens]
GTGGTCCTGTGGAAATCTAATCTTTCCATTTCATGGAAAACCCAGCTTTTTTCAACCAGCCTCCATGTGGGGGCGGGTAT
CATTTTGCTTGTTGCACCATGGGAACCTGGTAACTCGATGATTTGGCTTCCATTATTGGTTATCTTAGTGGCGAGCTGGG
CAAAAAGTCAAAAGAACATTAGCAAAGTGAAAGGCGTTGCTGTACTGGTGAATGGCAATAAGCTTCAATGGAAAAAGAAT
GAGTGGGAAATAATCAAAGCACCATGGTGTAGCCGTTGTGGTATTTTATTGACGCTTAAGGCACTGCAAGGAAAGCCACA
GAAGCTGCGTTTGTGGGTGGCGAAAGATTCAGTGTCCGAAGAAAATTGGCGTAACCTCAATCAATTATTACTGCAATATC
CCGACATTTGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11012.85 Da
• Isoelectric Point: 6.4729

>AT241884 WP_252055375.1 NZ_CP095276:c2992487-2992185 [Enterobacter hormaechei subsp. xiangfangensis]
MGRTLEQLIADEKPEVVASAQAMATDILLNIHLAELREKVQKTQVDMARALGIKQPTVAVMEKAGRDIKLSSLKRFVEAA
GGKLRLDVELPDGSHYEFVL

Nucleotide

• Length: 303 bp

>AT241884 NZ_OU659130:c2357576-2357310 [Providencia alcalifaciens]
ATCGATATCAATAACAAGGCGCGAATTCATTGGGCATGCAGAAGAGGCATGCGTGAGCTTGATATTTCTATCATGCCATT
TTTTGAATATGAATATGACGAACTGACAGATCACGATAAACGTATTTTTGTGCGTCTACTCGAGTGCCCAGATCCAGATT
TGTTCAATTGGTTGATGAATCACGGGCGTCCGGAGGATGAAGAGCTATTCTCTATGATTAAACTCATTCAAGAAAGAAAT
AAAAATCGTGGTCCTGTGGAAATCTAA

Structures

Toxin

• AlphaFold DB: A0A2J0Q4X0